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PEMANFAATAN SARI KULIT PISANG KEPOK (Musa paradisiaca L.) SEBAGAI MINUMAN FERMENTASI MENGGUNAKAN Lactobacillus plantarum B1765 Annisa Suci Hermansyah; Prima Retno Wikandari
Unesa Journal of Chemistry Vol. 14 No. 1 (2025): Vol 14 No 1 (2025)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/ujc.v14n1.p20-27

Kepok banana peel is an agricultural waste that has not been optimally utilised. Efforts are needed to utilise the waste that provides added value as a food product. Fermented beverage is one of the products that can be developed based on the nutritional potential of kepok banana peel. This study was conducted to determine the effect of variation in fermentation duration on product quality including microbiological quality (Total Lactic Acid Bacteria (LAB)), chemical quality (pH and Total Titratable Acid (TAT)) and organoleptic quality (Colour, Taste and Aroma) in kepok banana peel fermented beverage using Lactobacillus plantarum B1765. Fermentation was carried out for 0, 6, 12, 18, 24 and 30 hours at 37°C. Total LAB was calculated using the Total Plate Count (TPC) method, pH was determined using a pH meter, and TAT was tested using the acid-base titration method. Meanwhile, organoleptic was tested using the panellist's favourite level quality test. The results showed that the fermentation time reached the highest LAB growth up to 2.23 x 108 CFU/mL at 12 hours fermentation. pH decreased from 6.07 to 3.82 and TAT increased from 0.14% to 0.7% at 30 hours fermentation. Meanwhile, the level of panellists' liking reached an optimum at 24 hours with the category of liking. According to SNI 7552:2018 from the aspects of total LAB, TAT, and organoleptic, the best fermentation time is 24 hours.

Kajian Peningkatan Aktivitas Antioksidan pada Umbi-Umbian Melalui Fermentasi Nur Hasanah Jusman; Prima Retno Wikandari; Ratih Dewi Saputri
Jurnal Ilmiah Pangan Halal Vol. 7 No. 2 (2025): Jurnal Ilmiah Pangan Halal
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/jiph.v7i2.19321

Tubers are recognized as local food sources rich in bioactive compounds, particularly phenolics and flavonoids, which function as natural antioxidants. However, in many tubers, phenolic compounds are often bound in glycosidic forms, reducing their antioxidant effectiveness. To enhance their bioactivity, these glycosidic bonds can be hydrolyzed through fermentation, utilizing microorganisms with β-glucosidase activity such as Lactobacillus plantarum. This enzyme breaks glycosidic bonds, releasing glucose and aglycones in free forms that are more biologically active and possess greater antioxidant potential. As a result, the bioavailability and absorption of phenolic compounds in the human body are improved, enhancing their ability to neutralize free radicals. Several types of tubers, including Chinese yam, jicama, and cassava, have shown significant increases in total phenolic and flavonoid content after undergoing fermentation. Studies have demonstrated that fermentation not only boosts antioxidant activity but also supports the development of more nutritious and affordable functional food products derived from tubers. Nonetheless, the success of fermentation depends on several factors, including microbial strains, fermentation duration, environmental conditions, and processing techniques. This review aims to summarize current findings on how fermentation enhances antioxidant properties in tubers and its potential application in functional food innovation.

Open-Data Serum Metabolomics of Lung Adenocarcinoma for Equitable Early Detection under SDG Target 3.4 Muhammad Nurrohman Sidiq; Rudiana Agustini; Nuniek Herdyastuti; Prima Retno Wikandari; Mirwa Adiprahara Anggarani
Journal of Current Studies in SDGs Vol. 3 No. 4 (2027): December
Publisher : Sekolah Tinggi Agama Islam Sabilul Muttaqin Mojokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63230/jocsis.3.4.325

Objective: Sustainable Development Goal (SDG) target 3.4 addresses premature non-communicable disease mortality, yet lung cancer leads cancer mortality among Indonesian men, and low-dose computed tomography screening presumes imaging capacity most low-income settings lack. This study asked which serum pathways are recoverable from open lung adenocarcinoma metabolomics and whether their enzymes are altered in tumor tissue. Method: Serum GC-TOF MS data from the ST000385 ADC2 cohort (43 cases, 43 controls, 152 compounds) were reanalysed in MetaboAnalyst 6.0 using PLS-DA with permutation testing, multivariate ROC, and KEGG enrichment. Enzymes were examined in TCGA-LUAD (483 tumor, 347 normal) with GEPIA2 and survival analysis, and the cohort ST000386 underwent metadata testing. Results: The one-component model separated the groups (R² = 0.492, Q² = 0.302, permutation p < 5 × 10⁻⁴) and reached an AUC of 0.882 on five metabolites, which a sensitivity analysis showed to rest on one correlated axis. Twenty metabolites passed a 5% FDR, and arginine biosynthesis was the most enriched pathway (FDR = 5.8 × 10⁻⁵), whereas the TCA cycle and taurine metabolism did not survive correction. LDHA, PKM and CDO1 predicted survival. ARG1, OTC and CPS1 medians fell in tumor while ASS1 and ARG2 rose modestly. ST000386 carried subject-level metadata that does not associate with its own metabolome. Novelty: The dominant pathway is arginine biosynthesis rather than the Warburg axis of earlier readings, and the enzyme layer shows a dysregulated rather than silenced urea cycle.

Open-Data Serum Metabolomics of Lung Adenocarcinoma for Equitable Early Detection under SDG Target 3.4 Muhammad Nurrohman Sidiq; Rudiana Agustini; Nuniek Herdyastuti; Prima Retno Wikandari; Mirwa Adiprahara Anggarani
Journal of Current Studies in SDGs Vol. 3 No. 4 (2027): December
Publisher : Sekolah Tinggi Agama Islam Sabilul Muttaqin Mojokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63230/jocsis.3.4.325

Objective: Sustainable Development Goal (SDG) target 3.4 addresses premature non-communicable disease mortality, yet lung cancer leads cancer mortality among Indonesian men, and low-dose computed tomography screening presumes imaging capacity most low-income settings lack. This study asked which serum pathways are recoverable from open lung adenocarcinoma metabolomics and whether their enzymes are altered in tumor tissue. Method: Serum GC-TOF MS data from the ST000385 ADC2 cohort (43 cases, 43 controls, 152 compounds) were reanalysed in MetaboAnalyst 6.0 using PLS-DA with permutation testing, multivariate ROC, and KEGG enrichment. Enzymes were examined in TCGA-LUAD (483 tumor, 347 normal) with GEPIA2 and survival analysis, and the cohort ST000386 underwent metadata testing. Results: The one-component model separated the groups (R² = 0.492, Q² = 0.302, permutation p < 5 × 10⁻⁴) and reached an AUC of 0.882 on five metabolites, which a sensitivity analysis showed to rest on one correlated axis. Twenty metabolites passed a 5% FDR, and arginine biosynthesis was the most enriched pathway (FDR = 5.8 × 10⁻⁵), whereas the TCA cycle and taurine metabolism did not survive correction. LDHA, PKM and CDO1 predicted survival. ARG1, OTC and CPS1 medians fell in tumor while ASS1 and ARG2 rose modestly. ST000386 carried subject-level metadata that does not associate with its own metabolome. Novelty: The dominant pathway is arginine biosynthesis rather than the Warburg axis of earlier readings, and the enzyme layer shows a dysregulated rather than silenced urea cycle.

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