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All Journal Jurnal Penelitian Keperawatan Kontemporer (JPKK) Jurnal Penelitian Perawat Profesional
Winda Gusya
Universitas Airlangga
Health Professions Nursing

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Androgen Receptor, Resistensi Terapi, dan Pendekatan Terapeutik Baru pada Kanker Prostat Winda Gusya; Farabilla Fredela; Sekar Arum Firdausi; Ika Nur Pratiwi
Jurnal Penelitian Perawat Profesional Vol. 7 No. 6 (2025): Desember 2025, Jurnal Penelitian Perawat Profesional
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jppp.v7i6.1064

Abstract

Androgen receptor (AR) merupakan penggerak utama perkembangan kanker prostat dan tetap aktif meskipun kadar testosteron telah mencapai kondisi kastrasi. Resistensi terapi muncul melalui amplifikasi AR, mutasi ligand-binding domain (LBD), varian splice seperti AR-V7, bypass pathways (misalnya glucocorticoid receptor), serta aktivasi jalur non-AR seperti PI3K/AKT dan NF-κB. Tinjauan sistematis ini menganalisis mekanisme resistensi berbasis AR, peran jalur non-AR, serta efektivitas pendekatan terapeutik baru pada castration-resistant prostate cancer (CRPC). Systematic review dilakukan sesuai PRISMA 2020. PICO digunakan untuk merumuskan pertanyaan riset. Pencarian dilakukan pada PubMed, Scopus, Web of Science, dan Embase menggunakan kata kunci seperti “prostate cancer”, “castration-resistant prostate cancer”, “androgen receptor”, “AR-V7”, “antiandrogen resistance”, dan “novel AR-targeted therapy” dengan rentang publikasi 2015–2025. Screening dilakukan oleh dua reviewer independen. Kualitas studi dianalisis menggunakan RoB-2 dan Newcastle–Ottawa Scale. Dari 1.972 artikel yang teridentifikasi pada tahap awal, sebanyak 33 studi memenuhi kriteria inklusi dan disertakan dalam sintesis akhir. Lima tema utama ditemukan: (1) reaktivasi AR melalui amplifikasi, mutasi, dan AR-V7; (2) aktivasi jalur non-AR; (3) resistensi terhadap antiandrogen generasi baru; (4) terapi inovatif seperti PROTACs, AR-V7 degraders, N-terminal domain inhibitors, dan RNA interference; (5) pendekatan drug repurposing & strategi re-sensitisasi seperti Bipolar Androgen Therapy (BAT). Resistensi CRPC didorong oleh interaksi kompleks antara perubahan AR, jalur kompensasi non-AR, dan adaptasi epigenetik. Terapi multimodal berbasis biomarker menjadi arah masa depan pengelolaan CRPC.
Evidence-Based Nursing Interventions for Postoperative Cancer Patients: A Systematic Review winda gusya
Jurnal Penelitian Keperawatan Kontemporer Vol 6 No 2 (2026): April 2026
Publisher : Program Studi S1 Ilmu Keperawatan dan Ners IKBIS Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59894/jpkk.v6i2.1327

Abstract

Background: Cancer remains a leading cause of mortality worldwide, with surgical intervention being a primary treatment modality. Postoperative care is a critical phase that significantly influences patient recovery outcomes. Evidence-based nursing (EBN) has been recognized as an effective approach to improving postoperative care quality, yet no systematic review has specifically synthesized EBN interventions in the postoperative stage of cancer care. Objective: This study aims to systematically review and synthesize global evidence on evidence-based nursing interventions for postoperative cancer patients. Methods: A systematic review was conducted following PRISMA 2020 guidelines. Literature searches were performed across three databases — Scopus, PubMed, and Web of Science Core Collection — using Boolean search strategies. Studies published between 2015–2025, written in English, and focused on EBN interventions in postoperative oncology settings were included. Results: Fifteen studies met the inclusion criteria. Three major intervention categories were identified: (1) evidence-based nursing programs, (2) comprehensive/integrated nursing care, and (3) Enhanced Recovery After Surgery (ERAS)-based protocols. These interventions consistently demonstrated improvements in postoperative complication rates, psychological well-being, quality of life, functional recovery, length of hospital stay, and patient satisfaction. Conclusion: Evidence-based nursing interventions are effective in improving clinical and psychological outcomes among postoperative cancer patients. Integration of EBN into postoperative cancer care is essential and should be supported by targeted training and institutional commitment. Keywords: Evidence-based nursing, postoperative care, cancer, oncology, systematic review
Co-Authors Farabilla Fredela Ika Nur Pratiwi Sekar Arum Firdausi