Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal Indonesian Journal of Global Health Research
Iman Dwi Winanto
Universitas Sumatera Utara

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
The Relationship between High Heel Size Variation and Long Standing Duration on the Risk of Plantar Fasciitis Gusnur Gazali Ashari; Benny Benny; Iman Dwi Winanto
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1401

Abstract

Wound healing is a crucial aspect in orthopedics. Channa striata (snakehead fish) contains albumin and other bioactive compounds thought to accelerate wound healing To assess the effectiveness of Channa striata extract gel on wound healing in Wistar rats based on clinical (wound area) and histopathological (HEALS-A score) parameters. Laboratory experimental research with post-test only control group design using 27 male Wistar rats, divided into three groups: negative control (no treatment), positive control (Bioplacenton), and treatment (Vipalbumin gel). Evaluation of wound area was performed on days 0, 3, 7, and 14 using ImageJ. Histopathological examination was conducted using HE staining and HEALS-A scoring. Data were analyzed using ANOVA and Chi-Square tests.  On day 14, the mean wound area of the treatment group (7.1±2.8 mm²) was equivalent to the positive control (6.7±2.5 mm²), both significantly smaller than the negative control (54.2±32.5 mm²; p<0.001). HEALS-A scores showed significant differences between groups on days 3, 7, and 14 (p<0.001; p=0.001; p=0.001). Channa striata extract gel effectively accelerates wound healing clinically and histologically, with effectiveness equivalent to Bioplacenton.
Dose-Dependent Chondrotoxicity of Intra-Articular Vancomycin in New Zealand White Rabbits: A Prospective True Experimental Study Husnul Fuad Albar; Iman Dwi Winanto; Ahmad Syahril Anwar
Indonesian Journal of Global Health Research Vol. 8 No. 6 (2026): Indonesian Journal of Global Health Research: December 2026
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i6.2584

Abstract

Local vancomycin is increasingly used in orthopaedic procedures to increase antimicrobial exposure at the surgical site, but the concentration at which direct intra-articular exposure damages intact cartilage remains uncertain. This study aimed to determine whether intra-articular vancomycin produces concentration-dependent histopathological injury in New Zealand White rabbit knee cartilage. Twenty-eight male rabbits were randomised to saline control or vancomycin at 2.5, 5, or 7.5 mg/mL and observed for 14 days. Safranin-O/Fast Green-stained cartilage was assessed by blinded observers using Modified Mankin scoring and Osteoarthritis Research Society International grading. All animals completed follow-up without clinical infection or systemic adverse events. Mean Modified Mankin scores were 2.14 ± 0.69, 4.29 ± 1.25, 4.29 ± 1.98, and 7.71 ± 2.36 in the control, 2.5, 5, and 7.5 mg/mL groups, respectively; severe lesions occurred only at 7.5 mg/mL, affecting four of seven specimens. These findings demonstrate a concentration-related in vivo cartilage safety signal and provide tissue-level evidence that complements recent chondrocyte toxicity and local vancomycin pharmacokinetic studies.
Co-Authors Ahmad Syahril Anwar Benny Benny Gusnur Gazali Ashari Husnul Fuad Albar