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All Journal JPNM : Jurnal Pustaka Nusantara Multidisiplin Indonesian Journal of Global Health Research
Mutiara Hanif Syafitri
Universitas Islam Sultan Agung
Religion Humanities Economics, Econometrics & Finance Education Social Sciences

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The Effect of Combining Astaxanthin and Vitamin E on IL-1, IL-6, And CRP Levels Sampurna Sampurna; Rita Kartika Sari; Mutiara Hanif Syafitri; Nafla Aqilah; Saskia Febrian Dwi
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1419

Abstract

Carrageenan-induced inflammation binds to TLR-4, activating the NF-kβ pathway, which attracts macrophages to release proinflammatory cytokines, Interleukin-1 and Interleukin-6, leading to the production of CRP. Astaxanthin and vitamin E have anti-inflammatory effects, but their combined effects are poorly studied. This study examines whether astaxanthin combined with vitamin E reduces IL-6, IL-1, and CRP levels in male Wistar rats induced by carrageenan. This experiment used a post-test-only control-group design with groups: KN (standard feed), KS (1% carrageenan induction), and KP (combination of 0.72 mg/kgBW astaxanthin and 24.1 mg/kgBW vitamin E). ELISA was performed 24 hours after carrageenan induction. Parametric data analysis was performed, followed by a post hoc test. The results showed that IL-1 levels were highest in KS (1.61 pg/mL), followed by KP (0.42 pg/mL) and KN (0.28 pg/mL). Statistical analysis (one-way ANOVA and post hoc tests) identified significant differences among all groups (p<0.05). IL-6 levels decreased in KP (58.67 pg/mL) compared to KS (98.83 pg/mL). CRP levels were highest in KS (2.35 ng/mL), followed by KP (1.01 ng/mL) and KN (0.75 ng/mL), with KS showing a significant increase compared to KN (p<0.05). From these results, it can be concluded that the combination of astaxanthin and vitamin E has an anti-inflammatory effect on IL-6, IL-1, and CRP levels in male Wistar rats induced by carrageenan.
Efek Antiinflamasi Kombinasi Astaxanthin dengan Vitamin E terhadap Kadar Interleukin-1 (IL-1): Studi Eksperimental pada Tikus Putih Jantan Galur Wistar yang Diinduksi Karagenan Mutiara Hanif Syafitri; Sampuna
JPNM Jurnal Pustaka Nusantara Multidisiplin Vol. 4 No. 1 (2026): February : Jurnal Pustaka Nusantara Multidisiplin (ACCEPTED)
Publisher : SM Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59945/jpnm.v4i1.965

Abstract

Inflamasi merupakan reaksi tubuh pada jaringan akibat rangsangan yang menyebabkan cedera lokal melalui aktivasi TLR-4 yang ditandai dengan peningkatan Interleukin-1. Karagenan merupakan bahan yang dapat mengaktifkan inflamasi dengan berikatan pada reseptor TLR-4 sehingga mengaktifkan jalur NF-κB. Kombinasi astaxanthin dengan vitamin E memiliki peran antiinflamasi dan antioksidan sehingga dapat menekan aktivitas TLR-4 dan ROS. Tujuan dari penelitian ini untuk mengetahui efek antiinflamasi kombinasi astaxanthin dengan vitamin E terhadap kadar interleukin-1 pada tikus putih jantan galur wistar yang diinduksi karagenan. Penelitian ini menggunakan desain eksperimental rancangan post-test only control group design, terdiri dari 30 ekor tikus putih jantan galur wistar yang dibagi menjadi 3 kelompok: KN (normal), KS (sakit: karagenan 1%), dan KP (perlakuan: astaxanthin 0,72 mg/kgBB + vitamin E 24,1 mg/kgBB + karagenan 1%). Kadar IL-1 diukur menggunakan metode ELISA. Data dianalisis dengan uji Shapiro-Wilk, Levene, One Way ANOVA, dan uji Post Hoc Tamhanes. Rerata kadar IL-1 pada KN = 0,28 pg/mL, KS = 1,61 pg/mL, dan KP = 0,42 pg/mL. Hasil uji One Way ANOVA menunjukkan perbedaan signifikan antar kelompok (p=0,000). Uji Post Hoc Tamhanes menunjukkan terdapat perbedaan signifikan antara semua kelompok (p<0,05). Dari hasil penelitian ini dapat disimpulkan terdapat efek antiinflamasi kombinasi astaxanthin dengan vitamin E terhadap kadar interleukin-1 pada tikus putih jantan galur wistar yang diinduksi karagenan.
Co-Authors Nafla Aqilah Rita Kartika Sari Sampuna Sampurna Sampurna Saskia Febrian Dwi