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All Journal Meditory : The Journal of Medical Laboratory
Agung Brahmanthya Nadine Kepakisan
Faculty of Medicine, Udayana University, Denpasar, 80232, Indonesia
Biochemistry, Genetics & Molecular Biology Environmental Science

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EFFICACY AND SAFETY OF CHIMERIC ANTIGEN RECEPTOR-MODIFIED T CELL (CAR-T) THERAPY IN LYMPHOMA: AN UPDATED SYSTEMATIC REVIEW AND META-ANALYSIS I Gede Krisna Arim Sadeva; I Gede Wikania Wira Wiguna; Ni Wayan Armerinayanti; Putu Mirah Wahyu Subagia Putri; Christo Timothy Mamangdean; Putu Ari Shanti Dewi; Kadek Meryndha Kumala Tungga; I Komang Raditya Putra Pratama; Agung Brahmanthya Nadine Kepakisan; Komang Indra Parama  Arta
Meditory : The Journal of Medical Laboratory Vol. 14 No. 1 (2026): Meditory, Volume 14 No. 1 Tahun 2026
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v14i1.5125

Abstract

Abstract Background: Lymphoma (Hodgkin and non-Hodgkin) is a malignancy of the lymphatic system, with global prevalence reaching 2.8% and mortality rates reaching 248,700 cases each year. Therefore, Chimeric Antigen Receptor-Modified T cell therapy (CAR-T) was developed as a new approach to improve survival rates in lymphoma patients. Objective: This study aimed to evaluate the efficacy and safety of CAR-T cell therapy in lymphoma. Methods: PRISMA 2020 was used in the literature search and systematic review with the keywords "CAR-T Cell Therapy" and "Lymphoma". All statistical analyses were performed with R statistical software version 3.3 and MedCalc software version 22. A p-value ≤ 0.05 was considered statistically significant. Results: There were 16 studies involving 440 patients with lymphoma. The complete response rate was 62% (95% CI 55%-65%, I² = 40%). Meanwhile, cytokine release syndrome (CRS) occurred in 73% of cases (95% CI 49%-88%, I² = 80%). The overall Immune effector cell-associated neurotoxicity syndrome (ICANS) rate was 17% (95% CI 9%-30%, I² = 66%). There is no significant publication bias in all analyses (p-value>0.05). However, these results need to be interpreted with caution, considering the high heterogeneity in the pooled analysis results (I² > 50%).
Co-Authors Christo Timothy Mamangdean I Gede Krisna Arim Sadeva I Gede Wikania Wira Wiguna I Komang Raditya Putra Pratama Kadek Meryndha Kumala Tungga Komang Indra Parama  Arta Ni Wayan Armerinayanti Putu Ari Shanti Dewi Putu Mirah Wahyu Subagia Putri