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All Journal Journal of Natural Product for Degenerative Diseases
Novi Yantih
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Pancasila, Jakarta, Indonesia.
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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LC–MS in the Development of Natural Product Based Antidiabetic Drugs: A Systematic Review Kholilah Kholilah; Novi Yantih; Ridel Yosua Rumondor; Nur Pujiastuti
Journal of Natural Product for Degenerative Diseases Vol. 3 No. 2 (2026): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/v3i2.9692

Abstract

Natural products have great potential as a source for developing antidiabetic drugs, but matrix complexity and phytochemical variations are the main challenges in identifying bioactive compounds. This systematic literature review aims to evaluate the role of liquid chromatography–mass spectrometry (LC–MS) in the development of natural product-based antidiabetic drugs, particularly in type 2 diabetes mellitus (T2DM). The literature search was carried out following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using the PubMed, Scopus, Web of Science, and ScienceDirect databases. The study results show that LC–MS plays an important role in comprehensive phytochemical profiling, high-confidence metabolite identification, and dereplication of complex natural matrices. Integration of LC–MS with metabolomics and pharmacology approaches provides a deeper mechanistic understanding of antidiabetic effects, including modulation of glucose and lipid metabolism. However, methodological heterogeneity between studies is still an obstacle, so protocol standardization and bioinformatics integration are needed to increase translational relevance towards clinical applications.
Co-Authors Kholilah Kholilah Nur Pujiastuti Ridel Yosua Rumondor