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All Journal Jurnal Medik Veteriner ARSHI Veterinary Letters
Mokhamad Fahrudin
Division of Anatomy, Histology, and Embryology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Veterinary

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Short-term treatment of osteoarthritis-induced sheep with human umbilical cord–derived mesenchymal stem cells: A morphological and proteomic analysis Kusdiantoro Mohamad; Adrian Situmeang; Handina Rakhmawati; I Ketut Mudite Adnyane; Mokhamad Fahrudin; Nurhidayat Nurhidayat; Harry Murti; Andri Maruli Tua Lubis; Arief Boediono
Jurnal Medik Veteriner Vol. 9 No. 1 (2026): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol9.iss1.2026.106-123

Abstract

Knee joints are the primary sites affected by osteoarthritis (OA) in humans and animals. Although intra-articular human umbilical cord–derived mesenchymal stem cells (hUC-MSCs) show therapeutic promise, their combined use with hyaluronic acid (HA) remains underexplored in large animals. This study evaluated morphological and proteomic changes in a sheep osteoarthritis model treated with both agents. A total of twelve sheep were divided into four groups (n = 3 per group): control (normal and OA) and three treatment groups receiving hUC-MSCs, HA, or a combination of HA and hUC-MSCs (HA + hUC-MSCs). OA was induced by meniscectomy, and intra-articular injections were administered four weeks post-surgery. Macroscopic scoring was conducted according to the Osteoarthritis Research Society International system, while histological evaluation was performed using hematoxylin–eosin, Safranin O, and Masson’s trichrome staining. Proteomic analysis of synovial fluid was carried out using liquid chromatography–tandem mass spectrometry. The macroscopic OA score in the HA + hUC-MSC group was lower than in the other treatment groups and was not significantly different from the normal group (p > 0.05). Microscopic observations indicated that hUC-MSCs supported joint cartilage regeneration by preserving proteoglycan and collagen content. Proteomic profiling revealed that treatment with HA + hUC-MSCs modulated proteins associated with complement activation and coagulation pathways. The combination of HA and hUC-MSCs provided synergistic benefits for cartilage regeneration in a sheep OA model during a short treatment period. These findings suggest that this approach represents a promising regenerative therapy for OA in large animals within veterinary medicine and has translational relevance for human regenerative medicine.
Identifikasi bakteri enterik gram-negatif dan pola resistensi antimikroba pada burung psittacine yang dipelihara di Indonesia Arfah Herawana El Zamzami; Safika; Mokhamad Fahrudin; Muhammad Piter Kombo; Wisnu Rahmadan Almanda
ARSHI Veterinary Letters Vol. 9 No. 4 (2025): ARSHI Veterinary Letters - November 2025
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.9.4.111-112

Abstract

Psittacines are vulnerable to bacterial diseases, including gram-negative infections. A key challenge in treating these birds is antibiotic resistance, where antibiotics become ineffective against the bacteria. This study aimed to identify gram-negative bacteria present in 11 fecal samples of psittacine from Taman Mini Indonesia Indah (TMII) in East Jakarta, as well as to determine the presence of antibiotic resistance in these bacteria. In this study, bacteria were isolated using MacConkey Agar media, followed by Gram staining and biochemical tests for bacterial identification. Antibiotic resistance testing was conducted using the Kirby-Bauer method against seven antibiotics. The results of bacterial identification showed the presence of Klebsiella sp., Proteus mirabilis, and Escherichia coli in the fecal samples of Psittacine from TMII. Resistance to the antibiotics nalidixic acid, doxycycline, tetracycline, gentamicin, erythromycin, cefotaxime, and trimethoprim-sulfamethoxazole was observed, with trimethoprim-sulfamethoxazole demonstrating the lowest resistance rate among fecal Psittacine bacteria.
Co-Authors Adrian Situmeang Andri Maruli Tua Lubis Arfah Herawana El Zamzami Arief Boediono Handina Rakhmawati Harry Murti I Ketut Mudite Adnyane Kusdiantoro Mohamad Muhammad Piter Kombo Nurhidayat Nurhidayat Safika Wisnu Rahmadan Almanda