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Rekonseptualisasi Faktor Risiko dalam Kedokteran 2025 Raymond R. Tjandrawinata
MEDICINUS Vol. 39 No. 1 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/2ejq6e75

Abstract

The term “new risk factors” in the medical literature of 2025 rarely refers to the discovery of previously unknown disease determinants; rather, it reflects an epistemic shift in how risk is defined, measured, and interpreted. This perspectivehighlights how advances in objective measurement technologies, large-scale cohort analyses, and genetics-based causal approaches have brought renewed attention to factors that were previously under recognized or oversimplified. By examining examples such as multidimensionally measured sleep irregularity, wildfire smoke exposure as a cardiovascular determinant, chlorpyrifos pesticide exposure in neurodegenerative disease, and debates surrounding immune-relateddisease causality which assessed through Mendelian randomization, this article demonstrates that the “novelty” of riskfactors more often lies in the breadth of disease spectra and the depth of biological inference rather than in the variables themselves. Obesity and cancer are used as a conceptual framework to illustrate how clinical redefinition can reshape riskstratification and preventive strategies. This perspective argues that progress in modern medicine should not be measured by the expansion of risk factor lists, but by the capacity of scientific systems to assess risk with greater precision, contextual awareness, and orientation toward clinically meaningful outcomes.
Cinnamomum Adulteration: Scope, Detection Methodologies, Health Implications, and Regulatory Challenges A Global Review Raymond R. Tjandrawinata
Journal of World Science Vol. 5 No. 7 (2026): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v5i7.1682

Abstract

Cinnamon is among the world’s most economically significant spices, yet the genus Cinnamomum is one of the most frequently adulterated food commodity groups due to price differentials between premium Ceylon cinnamon and Cassia varieties, compounded by the visual indistinguishability of powdered products. This review—Cinnamomum Adulteration: Scope, Detection Methodologies, Health Implications, and Regulatory Challenges A Global Review—provides a comprehensive analysis of Cinnamomum adulteration encompassing botanical differentiation, adulteration typology, detection methodologies, health implications, and global regulatory architecture, with special attention to C. burmannii’s ambiguous regulatory status. It synthesizes peer-reviewed literature, regulatory documents, and international standards from 2004 to 2025, systematically analyzing detection platforms spanning classical, spectroscopic, chromatographic, and molecular DNA-based methods. The 2025 EU JRC study analyzing 104 commercial samples found that over 66% failed quality standards or exceeded coumarin limits, with species substitution confirmed in 9% of Ceylon-labeled products. Advanced detection methods include Bar-HRM, qPCR, NIR, EDXRF, and HPLC-DAD, enabling comprehensive authentication across multiple adulteration types. Health risks center on coumarin hepatotoxicity (Cassia: up to 12.18 mg/g; C. verum: 0.005–0.090 mg/g), heavy metal toxicity, and allergen mislabeling. Cinnamomum adulteration requires a species-specific, risk-based authentication framework supported by regulatory harmonization among ISO, Codex Alimentarius, and national agencies. The Codex Alimentarius Commission’s 2024 decision to initiate cinnamon standard development creates a policy window for action. Future priorities include harmonized coumarin limits, mandatory species labeling, heavy metal surveillance, and capacity building for molecular authentication in producing countries.