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All Journal Hayyan Journal
Wisye Riska Leleallo Sura'
Universitas Prof. Dr. H.M. Arifin Sallattang Bantaeng
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Medicine & Pharmacology

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Integrative Mapping of Phytochemistry, Pharmacology, Green Extraction, and Bioeconomics Peperomia pellucida (L.) Kunth: Systematic Literature Review Subakir Salnus; Ayu Sri Wiyanti; Hardianti Rahman; Yusran Katarina; Wisye Riska Leleallo Sura'; Andi Bau Andriwati
Hayyan Journal Vol. 3 No. 2 (2026): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v3i2.5183

Abstract

This study aims to integrate scientific evidence on phytochemistry, pharmacology, green extraction, and bioeconomics of Peperomia pellucida (L.). Kunth through the Systematic Literature Review approach. The research was conducted by searching the Scopus database for articles using keywords related to Peperomia pellucida, phytochemicals, pharmacology, extraction, toxicology, antioxidants, antibacterial activity, and antidiabetic activity. Of the initial 89 articles, the selection process across identification, screening, eligibility, and inclusion yielded 34 articles for narrative analysis. The study found that P. pellucida contains various bioactive compounds, including flavonoids, alkaloids, tannins, saponins, phenols, terpenoids, steroids, lignans, phenylpropanoids, essential oils, dillapiole, quercetin, apigenin, stigmasterol, and fucosterol. The compound exhibits antioxidant, anti-inflammatory, antidiabetic, antibacterial, antihypertensive, anticancer, gastroprotective, neuroprotective, antiarthritis, antimalarial, and wound-healing activities. Extraction techniques such as maceration, solvent fractionation, MAE, IL-MAE, NADES, fermentation, drying, and gamma irradiation have been shown to affect compound content, biological activity, safety, and extract quality. This study concludes that P. pellucida has the potential to be developed as an ingredient in herbs, functional foods, phytopharmaceuticals, cosmetics, topical products, bioaccharicides, and bioeconomic commodities, but still requires standardization, safety validation, and further research.
Multidimensional Mapping to Assess Phytochemical Diversity, Strength of Bioactivity Evidence, and Determinants of Variation in Mangrove Plants through a Mini Literature Review Subakir Salnus; Ayu Sri Wiyanti; Hardianti Rahman; Yusran Katarina; Wisye Riska Leleallo Sura'; Andi Bau Andriwati
Hayyan Journal Vol. 3 No. 2 (2026): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v3i2.5303

Abstract

This study aims to map phytochemical diversity, biological activity, strength of evidence, and factors that affect the variation in metabolite profiles in mangrove plants. The study used  a mini literature review  design with a multidimensional mapping approach to publications that discuss mangrove species, plant parts, extraction methods, compound identification techniques, and bioactivity testing. Data were collected through literature search, selection based on inclusion and exclusion criteria, structured data extraction, article quality assessment, and descriptive and narrative synthesis. The results showed that mangrove plants contain a diverse range of compounds, especially phenolics, flavonoids, tannins, alkaloids, saponins, steroids, glycosides, terpenoids, triterpenoids, limonoids, quinones, and fatty acids. The most commonly reported biological activities were antioxidants and antimicrobials, followed by anti-inflammatory, antidiabetic, anticancer, cytotoxic, hepatoprotective, analgesic, and neuroprotective activities. The phytochemical and bioactivity profiles are influenced by species, plant parts, tissue age, location, environmental conditions, solvent type, extraction techniques, purification, and analysis methods. Most of the evidence still comes from crude extracts and in vitro testing, while toxicity, pharmacokinetics, bioavailability, and clinical validation is still limited. This study concludes that mangroves have great potential as a source of bioactive compounds, but their utilization requires standardization of methods, tiered validation, and sustainable resource management.
Co-Authors Andi Bau Andriwati Ayu Sri Wiyanti Hardianti Rahman Subakir Salnus Yusran Katarina