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Indah Widyastuti
Politeknik Kesehatan TNI AU Ciumbuleuit
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Kajian Literatur: Produksi, Karakterisasi, dan Potensi Aplikasi Pati Pachyrhizus erosus: Literature Review: Production, Characterization, and Potential Applications of Pachyrhizus erosus Starch Indah Widyastuti
Jurnal Ilmiah JKA (Jurnal Kesehatan Aeromedika) Vol. 12 No. 1 (2026): Jurnal Ilmiah JKA (Jurnal Kesehatan Aeromedika)
Publisher : Politeknik Kesehatan TNI AU Ciumbuleuit Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58550/jka.v12i1.387

Abstract

Tinjauan ini mengkaji pati bengkuang (Pachyrhizus erosus) sebagai polisakarida alami yang memiliki karakteristik kristalinitas tipe A, plastisitas molekuler yang tinggi, serta sifat biodegradabilitas yang mendukung pemanfaatannya sebagai biopolimer farmasi. Beberapa faktor yang mempengaruhi antara lain: keterkaitan antara struktur, kondisi proses, dan kinerja fungsional pati bengkuang dalam konteks pengembangan sistem penghantaran obat. Berbagai studi eksperimental yang dianalisis menunjukkan bahwa pengaturan parameter proses, termasuk metode ekstraksi dan modifikasi pasca-ekstraksi, mampu mempengaruhi distribusi berat molekul, stabilitas termal, dan kemampuan pembentukan partikel. Ketiga aspek tersebut merupakan determinan penting bagi desain sistem penghantaran obat berbasis polisakarida, khususnya dalam pembentukan partikel mikro maupun nano yang terkontrol. Secara konseptual, sifat mudah terdegradasi melalui hidrolisis terarah dan potensi fungsionalnya menempatkan pati bengkuang sebagai kandidat menjanjikan untuk pembawa obat yang biokompatibel dan ramah lingkungan. Namun, implementasi pada formulasi farmasi masih memerlukan standardisasi parameter mutu, karakterisasi menyeluruh terhadap keamanan biologis, serta uji in vitro dan in vivo yang lebih komprehensif. Secara keseluruhan, kajian ini menegaskan bahwa pati bengkuang memiliki prospek signifikan sebagai biopolimer alternatif dalam pengembangan sistem penghantaran obat, sekaligus mengidentifikasi agenda riset lanjutan yang diperlukan untuk mendukung translasi ke aplikasi klinis. This review investigates yam bean (Pachyrhizus erosus) starch as a natural polysaccharide that exhibits A-type crystallinity, high molecular plasticity, and biodegradability, its support potential use as a pharmaceutical biopolymer. Particular attention is given to the interplay among structural features, processing conditions, and functional performance of yam bean starch in the context of drug delivery system development. Analysis of experimental studies indicates that adjusting processing parameters, including extraction methods and post-extraction modifications, can modify molecular weight distribution, thermal stability, and particle-forming ability. These three attributes are key determinants of the design of polysaccharide-based drug delivery systems, particularly for the controlled formation of micro- and nanoparticles. Conceptually, the ease of degradation through directed hydrolysis and the functional versatility of yam bean starch, position it as a promising candidate for biocompatible and environmentally friendly drug carriers. However, successful implementation in pharmaceutical formulations still requires standardisation of quality parameters, comprehensive characterisation of biological safety, and more extensive in vitro and in vivo evaluations. Overall, this review highlights the significant potential of yam bean starch as an alternative biopolymer for the development of drug delivery systems and identifies future research agendas needed to support its translation toward clinical applications.
Formulasi dan Evaluasi Karakteristik Fisik Sabun Mandi Cair Mengandung Minyak Atsiri Serai Dapur (Cymbopogon citratus): Formulation and Evaluation of the Physical Characteristics of a Liquid Body Wash Containing Lemongrass (Cymbopogon citratus) Essential Oil Indah Widyastuti; Isna Mulyani; Ai Yayuk
Jurnal Ilmiah JKA (Jurnal Kesehatan Aeromedika) Vol. 12 No. 2 (2026): Jurnal Ilmiah JKA (Jurnal Kesehatan Aeromedika)
Publisher : Politeknik Kesehatan TNI AU Ciumbuleuit Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58550/jka.v12i2.424

Abstract

Minyak atsiri serai dapur (Cymbopogon citratus) memiliki aroma khas dan berpotensi digunakan sebagai bahan tambahan dalam sediaan sabun mandi cair. Penelitian ini bertujuan mengevaluasi pengaruh penambahan minyak atsiri serai dapur terhadap karakteristik fisik sabun mandi cair. Penelitian dilakukan secara eksperimental  menggunakan empat formula, yaitu F0, F1, F2, dan F3. Dimana F0  sebagai kontrol dan formula lainnya mengandung minyak atsiri  1, 5 dan 10%. Minyak atsiri diperoleh melalui destilasi air, kemudia diuji skrining fitokimia  dan dianalisis menggunakan GC-MS. Evaluasi sediaan meliputi organoleptik, pH, homogenitas, tinggi busa dan stabilitas busa. Hasil skrining menunjukkan minyak atsiri positif  mengandung monoterpenoid/seskuiterpenoid dan terpenoid. Analisis GC-MS menunjukkan komponen utama berupa geranial, neral, mirsenal, dan geranil asetat. Seluruh formula memiliki pH basa  dalam rentang 8,61-10,25 dan stabilitas busa 76,25-91,25%. Uji one-way ANOVA menunjukkan konsentrasi minyak atsiri berpengaruh secara signifikan terhadpa pH, tetapi  tidak signifikan terhadap stabilitas busa. F2 dipertimbangkan sebagai formula yang paling seimbang.   Abstract Lemongrass (Cymbopogon citratus) essential oil has distinctive aromatic profile that has potential  as an additive in liquid body soap. This study evaluated changes in the physical characteristics of liquid soap following the incorporation of essential oil at different concentrartions. Four experimental formulations were prepared: a base formulation without essential oil (F0) and formulations containing 1% (F1), 5% (F2), and 10%(F3) essential oil. The essential oil was obtained by hydrodistillation and subsequently characterized by phytochemical screening and gas chromatography-mass spectrometry (GC-MS). The formulations were evaluated for organoleptic properties, pH, homogeneity, foam height, and foam stability. Preliminary phytochemical screening indicated the presence of monoterpenoids/sesquiterpenoids and terpenoids. GC-MS analysis identified geranial, neral, myrcene, and geranyl acetate as the major constituents. All formulations have basic pH of 8,61-10,25 and foam stability 76,25-91,25%. One-way analysis of variance showed  that essential oil concentration had a significant effect on pH (p<0.05), but no significant effect on foam stability (p>0,05). Overall, F2 was considered the most balanced formulation.
Co-Authors Ai Yayuk Isna Mulyani