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Rini Yanuarti
Institut Sains dan Teknologi Alkamal
Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Health Professions Medicine & Pharmacology

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FORMULASI, EVALUASI DAN UJI ANTIBAKTERI SEDIAAN GEL EKSTRAK ETANOL DUAN JAMBU BIJI (Psidium guajava L.) SEBAGAI ANTI JERAWAT Nurfitriyana Nurfitriyana; Rini Yanuarti; Indri Dyah Pangesti
IONTech Journal Vol. 2 No. 2 (2021): Agustus 2021
Publisher : Institut Sains dan Teknologi Al-Kamal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62702/ion.v2i2.48

Abstract

Acne is skin problems that can be overcome by using herbal plants, one of which is guava leaves. Guava leaves (Psidium guajava L.) contains tannins, saponins, polyphenols and flavonoids that can inhibit the growth of acne-causing bacteria. This study aims to formulate guava leaf extract (Psidium guajava L.) and evaluate the results of antibacterial tests on gel preparations as anti-acne. The ethanol extract was extracted and formulated using Na-CMC. Evaluation of the antibacterial activity of guava leaf extracts and preparations using Staphylococcus aureus and Eschericia coli bacteria. The results showed that the ethanol extract of guava leaves (Psidium guajava L.) with a concentration of 15% had antibacterial activity against Staphylococcus aureus with an inhibition area of ​​6.75 cm, and the gel preparation of guava leaf ethanol extract (Psidium guajava L.) resistance 0.2 mm. The evaluation found that the gel preparation of ethanol extract of guava leaves (Psidium guajava L.) can be used as an anti-acne gel.
ANALISIS INTERAKSI KIMIA FOURIER TRANSFORM INFRARED (FTIR) TABLET GASTRORENTIF EKSTRAK DAUN PETAI (Parkia speciosa Hassk) DENGAN POLIMER HPMC-K4M DAN KITOSAN Nurfitriyana Nurfitriyana; Najma Annuria Fithri; Fitria; Rini Yanuarti
IONTech Journal Vol. 3 No. 2 (2022): Agustus 2022
Publisher : Institut Sains dan Teknologi Al-Kamal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62702/ion.v3i2.69

Abstract

Ekstrak etanol daun petai (EDP) mengandung senyawa flavonoid, tanin, dan terpen yang berkhasiat untuk terapi tukak lambung. Formulasi sediaan gastroretentif EDP sistem gastrorentif bertujuan untuk memperlama waktu tinggal obat di lambung sehingga meningkatkan bioavalabilitas obat menggunakan polimer HPMC-K4M dan Kitosan. Penelitian ini berujuan untuk mengetahui interaksi kimia antara polimer HPMC-K4M dan kitosan dengan ekstak. Preparasi sediaan dilakukan dengan granulasi basah dengan perbedaan konsentrasi HPMC-K4M dan kitosan untuk F1 (10% : 5%), FA (25% : 5%), FB (10% : 20%), dan FAB (25% : 20%). Interaksi kimia menggunakan FTIR (Fourier Transform Infra Red) dan anilis kandungan senyawa menggunakan KLT (Kromatografi lapis tipis). Hasil penelitian menunjukkan bahwa Tablet dan ekstrak mengandung senyawa flavonoid, tanin dam terpen. Tidak terjadi interaksi kimia antara polimer HPMC-K4M dan kitosan dengan ekstrak yang dibuktikan dengan tidak terbentuknya gugus fungsi baru antara ekstrak dan polimer.
Co-Authors Fitria Indri Dyah Pangesti Najma Annuria Fithri Nurfitriyana Nurfitriyana