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All Journal Jurnal Impresi Indonesia
Bintang Yinke Magdalena Sinaga
Department of Pulmonology & Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Religion Economics, Econometrics & Finance Education Law, Crime, Criminology & Criminal Justice Social Sciences

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Contact Investigation Among Household Contacts of Drug-Resistant Tuberculosis Patients in Medan Handan Rizky; Bintang Yinke Magdalena Sinaga; Parluhutan Siagian; Taufik Ashar
Jurnal Impresi Indonesia Vol. 4 No. 8 (2025): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v4i8.6938

Abstract

Household contacts of Drug-Resistant Tuberculosis patients potential to develop latent tuberculosis infection (LTBI) or active tuberculosis (TB) infection. This research aims to determine the prevalence of LTBI and Pulmonary TB and the characteristic of household contact with Drug-Resistant Tuberculosis (DR-TB) patients. This is a descriptive analytical study using a cross-sectional approach in people aged > 18 years who have household contact with DR-TB patients whom confirmed by sputum GeneXpert and treated at Adam Malik Hospital Medan. The research subjects then underwent examinations including symptom anamnesis, chest X-ray, sputum GeneXpert, and IGRA blood test From 105 people who had household contact with DR-TB patients, the most common cases found were LTBI cases (55%), followed by uninfected cases (40%). Meanwhile, the only cases of Pulmonary TB found were Drug-Sensitive Pulmonary TB were 6 cases (5%) which are bacteriologically confirmed drug-Sensitive TB was 4 cases and clinically confirmed drug-sensitive TB was 2 cases. Majority of patients were in 18-30 year old group (30.5%), female (70%), high school graduates (61%), housewives (41%), normoweight (80%), no smoking habit (78%), no consuming alcohol (97%), and no comorbid diseases (87.5%). Based on contact duration, 70 people (67%) were found with > 5 hours and 35 patients (33%) with < 5 hours. In addition, the majority of samples (70%) did not sleep in the same room with MDR-TB patients.  LTBI cases were the most common cases found among household contact with DR-TB patients.
Association Between Glycated Hemoglobin (HBA1C) Levels and The Incidence of Pulmonary Drug-Resistant Tuberculosis Among Patients With Type 2 Diabetes Mellitus Kartini Harahap; Fajrinur Syarani; Bintang Yinke Magdalena Sinaga; Putri Chairani Eyanoer
Jurnal Impresi Indonesia Vol. 4 No. 8 (2025): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v4i8.6939

Abstract

Patients with type 2 diabetes mellitus (T2DM) are at increased risk of developing multidrug-resistant tuberculosis (MDR-TB). In Indonesia, data regarding the characteristics and risk factors for MDR-TB among diabetic populations remain limited. Managing MDR-TB in individuals with T2DM is complicated by potential drug interactions and challenges associated with poor glycemic control. This study aimed to assess the association between glycated hemoglobin (HbA1c) levels and the risk of developing MDR-TB among T2DM patients at Adam Malik General Hospital, Medan. A case-control analytical study was conducted using secondary data from medical records. A total of 120 participants were, including 60 MDR-TB cases and 60 drug-sensitive tuberculosis controls. Variables analyzed included age, sex, education, employment status, body mass index, smoking status, and HbA1c levels. Statistical analyses involved chi-square tests and multivariate logistic regression. Multivariate analysis identified smoking as the strongest risk factor for MDR-TB, followed by poor glycemic control, indicated by elevated HbA1c levels. Smoking substantially increases the risk of MDR-TB among patients with T2DM, with smokers being twelve times more likely to develop MDR-TB. These findings emphasize the need to integrate smoking cessation initiatives into MDR-TB prevention and management strategies targeting diabetic populations.
Co-Authors Fajrinur Syarani Handan Rizky Kartini Harahap Parluhutan Siagian Putri Chairani Eyanoer Taufik Ashar