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All Journal Journal of Epidemiology and Public Health Journal of Health Promotion and Behavior World Nutrition Journal
Dono Indarto
Faculty of Medicine, Universitas Sebelas Maret
Medicine & Pharmacology Public Health

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The role of maltodextrin in iron nanoparticle formulations for food fortification and pharmaceutical applications: A scoping review Rizki Ananda; Dono Indarto; Yuliana Heri Suselo
World Nutrition Journal Vol. 9 No. i2 (2026): WNJ. Volume 09 Issue 2, February 2026
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V09.i2.0005

Abstract

Background: Iron nanoparticle formulation is an innovative approach to enhance the stability and bioavailability of iron, which is crucial in addressing global iron deficiency. However, conventional iron supplementation strategies, like oral ferrous sulfate, face limitations in absorption and bioavailability. Specifically, dietary inhibitors and gastrointestinal conditions can impede iron uptake. Moreover, oral iron supplements often cause side effects such as nausea, constipation, and abdominal discomfort, affecting patient compliance. These challenges highlight the need for innovative approaches to enhance iron delivery. In this context, nanotechnology offers a promising solution to conventional iron supplementation limitations. Iron nanoparticles provide improved solubility, targeted delivery, and controlled release, thereby enhancing therapeutic effectiveness. Both in vitro and in vivo bioavailability studies have demonstrated that nanoparticle-based formulations improve iron absorption and reduce side effects. By improving iron absorption and reducing side effects, nanoparticle-based formulations represent a significant advancement in IDA management. Maltodextrin, a water-soluble and neutral starch-derived polysaccharide, serves as an effective encapsulating agent in nanoparticle formulation, enhancing stability, solubility, and controlled release, thereby overcoming limitations of traditional iron supplementation. Both in vitro and in vivo studies have demonstrated the potential of maltodextrin-based iron nanoparticles to improve bioavailability and therapeutic outcomes. Objective: This scoping review aims to explore the role of maltodextrin in iron nanoparticle formulations based on the latest scientific evidence. Methods : A systematic literature search was conducted across four databases: PubMed, ScienceDirect, Scopus, and SpringerLink, using structured keywords. Inclusion criteria consisted of original English language articles published between 2019 and 2024 that discussed the use of maltodextrin in iron nanoparticle systems. Exclusion criteria The selection and data synthesis process followed PRISMA-ScR guidelines. Results : Out of 8620 articles identified, three met the inclusion criteria: Arazo-Rusindo et al. (2023), Kumari et al. (2023), and Baldelli et al. (2023). These studies demonstrated that maltodextrin acts as a carrier, stabilizer, and bioavailability enhancer, while also improving encapsulation efficiency and nanoparticle stability. Conclusions : These findings highlight the potential of maltodextrin in developing functional food products and pharmaceutical formulations based on iron nanoparticles; however, further research is needed to optimize formulations and evaluate long-term safety.
A Meta-Analysis on the Risk Factors of Low Back Pain in Health Workers Muh. Syaiful Akbar; Setyo Sri Rahardjo; Dono Indarto
Journal of Epidemiology and Public Health Vol. 5 No. 2 (2020)
Publisher : Masters Program in Public Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.057 KB)

Abstract

Background: Low back pain is a common prob
Multilevel Analysis: The Contextual Effect Village on The Risk Hypertension in Magelang, Central Java Wawan Diyantana; Dono Indarto; Bhisma Murti
Journal of Epidemiology and Public Health Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.692 KB)

Abstract

Background: Hypertension affects one billion people worldwide. Death due to hypertension in the world is estimated at 9.4 million people every year. Factors related to lifestyle can increase the risk of hypertension. In addition, demographic and topographic factors of resi
Meta Analysis the Effect of Body Mass Index on the Flat Foot Incidence Philipus Prihantiko Kurniagung; Dono Indarto; Setyo Sri Rahardjo
Journal of Epidemiology and Public Health Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.024 KB)

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Background: Musculoskeletal disorders in the form of flat foot, back pain and knee pain are often found in people who are obese. Flat foot is a musculoletal disorder characterized by a decrease or decrease in the height of the medial arch as a parameter, especially those that can be observed and measured in height. This study aims to estimate the average size of the effect of BMI on the risk of flat foot.Subjects and Method: Meta-analysis study and systematic reviews were applied to this study using the electronic database Pubmed, Science Direct, Google Scholar and Springer Link. Keywords to search for articles are as follows: "flat foot", "adult flat foot", "Flexible Flat Foot", "Body Mass Index", "Pediatric flat foot", "pes planus", "obesity", "overweight", "Ado
Theory of Planned Behavior Implementation on the Factors Affecting Self-Care Management in Type 2 Diabetes Mellitus Patients Ana Damayanti; Didik Tamtomo; Dono Indarto
Journal of Health Promotion and Behavior Vol. 3 No. 2 (2018)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (523.734 KB)

Abstract

Background: Diabetes mellitus (DM) is one of the largest global health emergencies in the 21st century. Diabetes self-management education (DSME) is a continuous process of knowledge transfer in order to improve skill and ability of diabetic patient to perform self-care management, which reduces blood glucose level and prevent diabetic complications. The success of DSME is determined by behavior changes of diabetic patients, which can be assessed using behavior theories including Theory of Planned Behavior (TPB). This study aimed to analyze the factors affecting self-care management in patients with type 2 DM using TPB.Subjects and Method: A randomized controlled trial study was carried out in 7 community health centers in Tarakan City, North Kalimantan, from March to May, 2018. A sample of 126 type 2 DM patients was selected by simple random sampling. The dependent variable was self-care management. The independent variables were intention, attitude, subjective norm, self-efficacy, and education level. The data was collected by questionnaire and analyzed by path analysis.Results: Self-care management was positively and directly affected by education ?senior high school (b= 7.10; SE= 3.22; p= 0.028) and strong intention (b= 2.40; SE= 0.75; p= 0.001). Self-care management was indirectly affected by self-efficacy, attitude, and subjective norm trough intention.Conclusion: Self-care management in type 2 DM is directly affected by education and strong intention. These findings support the TPB implementation in self-care management.Keywords: self- care management, type 2 DM, Theory of Planned BehaviorCorrespondence:
Effects of Chronic Disease Control Club on Physical Activity, Anxiety, and Blood Sugar Level: A Path Analysis Evidence Fajar Alam Putra; Dono Indarto; Ruben Dharmawan
Journal of Health Promotion and Behavior Vol. 4 No. 2 (2019)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.687 KB)

Abstract

Background: Diabetes mellitus (DM) is a serious chronic disease with a tendency to worsen. The number of DM cases worldwide in 2015 was 415 million people and is expected to increase by 642 million cases in 2040. Indonesia ranks 7th in the world with 10 million DM cases in 2015, around 90% of which are Diabetes Mellitus Type 2. This study aimed to determine the effects of chronic disease control club on physical activity, anxiety, and blood sugar level.Subjects and Method: This was a cross sectional study conducted at Sukoharjo health center, Sukoharjo, Central Java, from August to September 2018. A sample of 245 type 2 DM patients was selected for this study. The independent variables were physical activity, anxiety, chronic disease control club, and complications. Data were collected using HARS, physical activity, complication and club activitiesquestionnaires. Data were analyzed by using path analysis.Results: Anxiety directly increased with com­plication (b= 12.55; 95% CI= 111.98 to 13.90; p<0.001). Anxiety directly de­cre­ased with chronic disease control club (b= -3.29; 95% CI= -4.72 to -1.85; p<0.001). Fasting blood sugar directly incre­ased with anxiety (b= 2.78; 95% CI= 1.32 to 4.24; p<0.001) and complication (b= 33.14; 95% CI= 8.40 to 57.87; p= 0.009). Fasting blood sugar directly decre­ased with physical activity (b= -15.12; 95% CI= -19.89 to -10.35; p<0.001) and chro­nic disease control club (b= -30.14; 95% CI= -48.80 to -11.48; p= 0.002).Conclusion: Anxiety directly increases with com­plication. Anxiety directly de­cre­ases with chronic disease control club. Fasting blood sugar directly incre­ases with anxiety and compli­cation. Fasting blood sugar directly decre­ases with physical activity and chro­nic disease control club.Keywords: blood sugar level, physical activity, anxiety, chronic disease control clubCorrespondence: Fajar Alam Putra. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java. Email: bolodewe88@gmail.comJournal of Health Promotion and Behavior (2019), 4(3): 137-144https://doi.org/10.26911/thejhpb.2019.04.02.06
Co-Authors Ana Damayanti Bhisma Murti Didik Tamtomo Fajar Alam Putra Muh. Syaiful Akbar Philipus Prihantiko Kurniagung Rizki Ananda Ruben Dharmawan Setyo Sri Rahardjo Wawan Diyantana Yuliana Heri Suselo