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All Journal Journal of Epidemiology and Public Health
Nindita Arum Veibiani
Master’s Program in Public Health, Universitas Sebelas Maret
Public Health

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Factors Affecting Mortality in People Living with HIV with Antiretroviral Therapy: A Meta-Analysis Fauziah Shinta Anindita; Fenita Indriani; Bhisma Murti; Nindita Arum Veibiani
Journal of Epidemiology and Public Health Vol. 9 No. 4 (2024)
Publisher : Masters Program in Public Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/jepublichealth.2024.09.04.08

Abstract

Background: TB is the leading cause of death among people living with HIV. In 2020, an estimated 214,000 people living with HIV died from TB. People with AIDS have a severely damaged immune system. They are increasingly suffering from severe diseases, called opportunistic infections (OI). This study aims to analyze and estimate the influence of gender, TB Coinfection, Opportunistic Infection on mortality in ODHIV with Antiretroviral Therapy.Subjects and Method: Systematic review and meta-analysis using PRISMA flowchart and the PICO model. Population: ODHIV with ART. Intervention: Women, Co-infected TB, Opportunistic Infections. Comparison: Male, no co-infected TB, no Opportunistic Infection. Outcome: Mortality Article search using Google Scholar, PubMed and Science Direct databases. The keywods used include "HAART" or "HIV" or "HIV/AIDS" and "Gender" and "TB Coinfections" or "TB" and "Opportunistic Infections" and "Mortality" and "Antiretroviral Treatment". The 17 included articles are fulltext in English with a cohort design study from 2008 to 2023 and report on the Hazard Ratio in a multivariate analysis. Data analysis using the RevMan 5.3 application.Results: A total of 17 cohort studies involving 23,651 research subjects from Vietnam, China, Japan, Ethiopia, and South Africa. The data collected showed that female ODHIV had a mortality risk of 0.7 times compared to male ODHIV (aHR= 0.70; CI 95%=0.60 to 0.79; p<0.001). In ODHIV with coinfected TB has a mortality risk of 1.86 times compared to ODHIV without coinfected TB (aHR= 1.89; CI 95%=1.36 to 2.61; p<0.001). ODHIV with Opportunistic Infection has a 1.90-fold risk of mortality compared to ODHIV without Opportunistic Infection (aHR= 1.90; CI 95%=1.50 to 2.42; p<0.001).Conclusion: Female gender decreases the risk of mortality, while TB coinfection and Opportunistic infection increase the risk of mortality in ODHIV with Antiretroviral Therapy.
Effects of Hypertension, Diabetes Mellitus, and Gender on Post Stroke Cognitive Impairment: Meta-Analysis Sukandriani Utami; Emirza Nur Wicaksono; Amalia Choirunnisa; Nindita Arum Veibiani; Bhisma Murti
Journal of Epidemiology and Public Health Vol. 9 No. 1 (2024)
Publisher : Masters Program in Public Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/jepublichealth.2024.09.01.07

Abstract

Background: Post-stroke cognitive impairment is a serious problem that is often faced by indivi-duals who have experienced a stroke. This study aims to determine and estimate the effects of hypertension, diabetes mellitus, and gender on post-stroke cognitive impairment through meta-analysis of primary research conducted by previous researchers.Subjects and Method: This was a meta-analysis study using the PICO model which includes; P: post-stroke patients. I: hypertension, diabetes mellitus, and women. C: normotensive, without diabetes mellitus, and men. O: post-stroke cognitive impairment. A systematic search for primary studies was carried out in the PubMed database which was published from 2014 to 2023. The keywords used to search for primary studies were "Hypertension" AND "Diabetes Mellitus" AND "Post Stroke Cognitive Impairment". The inclusion criteria for the articles searched were primary studies with cross-sectional and cohort studies from 2014-2023 and reporting aOR values. Primary studies were selected using the PRISMA diagram and relevant primary studies were analyzed using Review Manager 5.3.Results: There were 18 primary studies with cross-sectional and cohort study designs. The total sample obtained through a systematic review and meta-analysis was 9,103 post-stroke patients from France, China, Singapore, the Netherlands, Egypt, Ethiopia, and Uganda. The results of the analysis showed that hypertension increased the risk 1.56 times (aOR= 1.56; 95% CI= 1.11 to 2.19; p= 0.010) and diabetes mellitus increased the risk 1.58 times (aOR= 1.58; 95% CI= 1.23 to 2.05; p< 0.001) post-stroke cognitive impairment compared to people without hypertension and diabetes. Meanwhile, the female gender increases the risk of post-stroke cognitive impairment by 1.28 times (aOR= 1.28; 95% CI=1.16 to 1.42; p<0.001). The data is statistically significant.Conclusion: hypertension, diabetes mellitus, and female gender increase the risk of post-stroke cognitive impairment. Keywords: Hypertension, diabetes mellitus, women, post-stroke cognitive disorders
Co-Authors Amalia Choirunnisa Bhisma Murti Emirza Nur Wicaksono Fauziah Shinta Anindita Fenita Indriani Sukandriani Utami