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All Journal Jurnal Pembelajaran dan Biologi Nukleus
Annisa Frastica Septi
Pharmacy, Faculty of Health Sciences, Universitas Singaperbangsa Karawang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media

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The Influence of Genetic Variations in CYP1A2 Associated with Clozapine Metabolism in Schizophrenia Patients Fathina Annajla; Annisa Frastica Septi; Nanda Diva Meilani; Aurora Fatimatuz Zahro
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 10, No 3: Jurnal Pembelajaran Dan Biologi Nukleus November 2024
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v10i3.6182

Abstract

Schizophrenia is a severe mental disorder that affects how a person thinks, feels, and behaves. Antipsychotic drugs are the treatment of choice for patients with schizophrenia. Clozapine is an atypical antipsychotic with unique efficacy in treatment-resistant schizophrenia. However, genetic variations in CYP1A2 can influence the differences in the activity of this enzyme, which in turn can affect the metabolism of clozapine and the response to treatment. This review aims to examine the impact of CYP1A2 genetic variations on clozapine metabolism in patients with schizophrenia. This review is prepared using the narrative literature review method, literature search was conducted through PubMed over the past ten years (2014-2024) using relevant keywords. The findings indicate that CYP1A2 genetic variations *1F is an ultrarapid metabolizer whose activity is strengthened by the presence of cigarettes, while *1C and *1D shows a decrease in CYP1A2 enzyme metabolism. This review underscores the importance of considering genetic factors, particularly CYP1A2, in tailoring treatment plans for schizophrenia patients
Co-Authors Aurora Fatimatuz Zahro Fathina Annajla Nanda Diva Meilani