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All Journal Vitamedica: Jurnal Rumpun Kesehatan Umum Jurnal Ilmiah Ilmu Kesehatan
Muhammad Rifqi Al Azim
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Religion Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Potensi Probiotik Lactobacillus casei dari Dadih Yogurt Minangkabau untuk Restorasi Mikrobiota Usus pada Irritable Bowel Syndrome : Sebuah Tinjauan Literatur Muhammad Rifqi Al Azim; Helena Azriz; Rizka Fauziah
PrimA: Jurnal Ilmiah Ilmu Kesehatan Vol. 11 No. 2 (2025): PrimA: Jurnal Ilmiah Ilmu Kesehatan
Publisher : LPPM STIKES Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47506/z909he94

Abstract

Pendahuluan : Sindrom iritasi usus atau yang biasa disingkat dengan IBS adalah gangguan fungsional pencernaan yang ditandai dengan gejala nyeri perut yang berulang dan perubahan kebiasaan buang air besar (misalnya sembelit, diare, atau keduanya), yang sering disertai perut kembung. Metode : Penelitian ini menggunakan desain Literature Review. Penelitian dilakukan dengan melakukan pencarian di internet menggunakan mesin pencarian jurnal. Mesin pencarian jurnal yang digunakan pada penelitian ini meliputi Pubmed, Google Scholarr, Science Direct, dengan kata kunci: “Mikrobiota usus, Sinbiotik, Dadih, Irritable Bowel Syndrome”. Hasil : Hasil yang didapatkan dari penelusuran e-resources Google Scholar sebanyak 204 PubMed NCBI sebanyak 90, dan  ScienceDirect sebanyak 10. Dari total    artikel tersebut, dilakukan eksklusi terhadap beberapa artikel yang terduplikasi pada database yang berbeda. Setelahdilakukan screening terhadap judul dan abstrak, ditemukan sebanyak 7 artikel yang berkaitan dengan topik yang akanditeliti serta memenuhi kriteria inklusi. Kesimpulan : Interaksi antara sistem imun, mikrobiota usus, dan genotipe inang diduga mendasari patogenesis IBS, berupa terjadinya ketidakseimbangan mikrobiota usus. Lactobacillus casei asal dadih dapat digunakan sebagai terapi alternatif IBS yang minimal efek samping karena bersifat probiotik.
Platelet Membrane-Coated Nanoparticles Sebagai Sistem Penghantaran Aspirin Daninhibitor P2Y12 Pada Penatalaksanaan Infark Miokard Akut : A Literature Review Muhammad Rifqi Al Azim; Fawwaz M Virajati; Saminur Muzaqi; Muhammad Althariq Huda
VitaMedica : Jurnal Rumpun Kesehatan Umum Vol. 4 No. 3 (2026): Juli : VitaMedica : Jurnal Rumpun Kesehatan Umum
Publisher : STIKES Columbia Asia Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62027/vitamedica.v4i3.911

Abstract

Background: Acute myocardial infarction (AMI) is a severe manifestation of coronary artery disease, commonly caused by atherosclerotic plaque rupture and thrombus formation. Dual antiplatelet therapy with aspirin and P2Y12 inhibitors is a cornerstone of AMI management but remains limited by bleeding risk and nonspecific drug distribution. Platelet membrane-coated nanoparticles (PM-NPs) are biomimetic drug delivery systems with potential for targeted therapy. Objective: To review the potential of PM-NPs for delivering aspirin and P2Y12 inhibitors in AMI management. Methods: A literature review was conducted using PubMed, ScienceDirect, and Google Scholar with the keywords “platelet membrane-coated nanoparticles,” “aspirin,” “P2Y12,” and “acute myocardial infarction.” Articles published within the last 10 years, available in full text, and written in English or Indonesian were selected according to predefined criteria. Twelve relevant articles were identified after screening. Results: PM-NPs demonstrated potential for targeting thrombi, atherosclerotic plaques, and injured myocardial tissue. They may improve drug stability, circulation time, and targeted delivery while reducing oxidative stress, inflammation, and ischemia-reperfusion injury. However, evidence regarding combined aspirin and P2Y12 inhibitor delivery remains limited and predominantly preclinical. Conclusion: PM-NPs represent a promising targeted antithrombotic platform for AMI. Further studies are required to establish the safety and efficacy of combined aspirin and P2Y12 inhibitor delivery.
Co-Authors Fawwaz M Virajati Helena Azriz Muhammad Althariq Huda Rizka Fauziah Saminur Muzaqi