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All Journal JFA (Jurnal Fisika dan Aplikasinya)
Adita Sutresno Adita Sutresno
Program Studi Fisika, Fakultas Sains dan Matematika, Universitas Kristen Satya Wacana, Jl. Diponegoro 52-60, Salatiga 50711
Physics

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Studi Difusi Ca2+ Pada Sinapsis Menggunakan Metode Monte Carlo Cell: Ester Ratna Sari, Giner Maslebu, Adita Sutresno Ester Ratna Sari Ester Ratna Sari; Giner Maslebu Giner Maslebu; Adita Sutresno Adita Sutresno
Jurnal Fisika dan Aplikasinya Vol 16 No 1 (2020): January 2020 Edition
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat, LPPM-ITS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j24604682.v16i1.5076

Abstract

Diffusion process became one of the important mechanisms in the human body system, such as in the nervous system which is the Ca2+diffusion in the synapses. This research aims to study the Ca2+diffusion process if Gd inhibits Ca2+channel in pre-synapses. This study did not use Gd, but it was modeled with various numbers of Ca2+ channels. The less number of Ca2+opened channels described the more Gd which inhibited Ca2+ channels. The Monte Carlo Cell Method (MCell) was used in this study. The synapses model was made using Blender 2.76b; consisted of two compartments illustrated with two circles. The molecule in the outside pre-synapses compartment interacted with the molecular surface of the pre-synapses compartment and resulted in a molecule in pre-synapses. The result of the simulation process for the molecules reached half of the variations in the number of total area channels. The time needed being 0.65s, 0.34s, 0.24s, and 0.18s, from the smallest to the biggest respectively. The times needed for density variations from big to small were 0.337s, 0.362s, and 0.364s respectively. The number of the diffused molecules in the backward rate variation within the same time was 3928, 3626, 2037, and 529 molecules respectively.
Studi Proses Difusi melalui Membran dengan Pendekatan Kompartemen: Fransiska Retno Kuntari, Susatyo Pranoto, Adita Sutresno Fransiska Retno Kuntari Fransiska Retno Kuntari; Susatyo Pranoto Susatyo Pranoto; Adita Sutresno Adita Sutresno
Jurnal Fisika dan Aplikasinya Vol 15 No 2 (2019): June 2019 Edition
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat, LPPM-ITS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j24604682.v15i2.4617

Abstract

Diffusion is an important process in daily life, especially in the system of the human body. In this study, the diffusion process in human body system was studied using the compartments approach. The purpose of this study is to examine the effect of channel area, concentration, and diffusion coefficient on the rate of diffusion. Two compartments each sized were separated by a perforated barrier that represents areas of high and low concentrations, which were connected by a channel. Two Conductivity Probe sensors were placed in each compartment with the same distance to the barrierand were connected with a Vernier interface and a computer that hadLogger Lite 1.9.4 installed. The conductivity data is converted into concentration, then analyzed. The compartment model can be used to study diffusion process in the human body system. Diffusion rate is directly proportional to channel area, concentration and diffusion coefficient.  
Co-Authors Ester Ratna Sari Ester Ratna Sari Fransiska Retno Kuntari Fransiska Retno Kuntari Giner Maslebu Giner Maslebu Susatyo Pranoto Susatyo Pranoto