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CORRELATION BETWEEN APOPROTEIN B/APOPROTEIN A-I RATIO WITH HOMA IR VALUE (HOMEOSTATIC MODEL ASSESMENT INSULIN RESISTANCE) IN TYPE 2 DIABETES MELLITUS Afandi, Muhammad Rafli; Marpaung, Ferdy Royland
Journal of Vocational Health Studies Vol. 3 No. 2 (2019): November 2019 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (157.353 KB) | DOI: 10.20473/jvhs.V3.I2.2019.78-82

Abstract

Background: Diabetes mellitus (DM) is the seventh leading cause of death in the world (the occuring rate has reached 400 million people). Type2 DM is caused by the body cells' inability to respond normally to insulin (insulin resistance). Homeostatic Model Assessment-Insuline Resistance (HOMA-IR) is a calculation method which function is to measure the body insulin resistance. Diabetes mellitus can cause lipid metabolism disorders (dyslipidemia) resulting in an increased level of LDL cholesterol and decreased HDL cholesterol. The apoprotein B/apoprotein A-I ratio is the result of comparisons of apoprotein B (LDL protein constituent) and apoprotein A-I (HDL protein constituent). The apo B/apo A-I ratio represents a balance between LDL cholesterol (atherogenic) and HDL (anti-atherogenic). It is astrong signifier in predicting heart disease. Purpose: This study aim to determine the correlation between the apoprotein B/apoprotein A-I ratio with HOMA-IR in patients with type 2 diabetes mellitus. Method: Observasional, consecutive, 100 people with type 2 diabetes mellitus who is examined in apoprotein B, apoprotein A-I test that calculating the ratio in which ratio are calculated, as well as HOMA-IR in Parahita Clinical Laboratory Surabaya. This study uses Pearson correlation test method with SPSS 22.0 for Windows program. Result: The result of Pearson correlation test between apoprotein B/apoprotein A-I ratio with HOMA-IR in 100 samples is a strong and significant correlation value  (r=0,610, p<0,05). Conclusion: There is a strong correlation between the apoprotein B/apoprotein A-I ratio with HOMA-IR in patients with type 2 diabetes mellitus.
Blood Q Creatinine Based on Sex and Age in Healthy Indonesian Geriatrics Marpaung, Ferdy Royland; Santoso, Djoko; Cavalier, Etienne; Aryati, Aryati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2726

Abstract

Median blood creatinine (Qcr) is necessary for an accurate evaluation of geriatric renal function. Nonetheless, there is a significant void in existing literature concerning creatinine reference data unique to the elderly. To improve diagnostic precision and clinical decision making in this susceptible group, this study developed a corresponding Q model for serum creatinine in geriatric patients stratified by age and sex. To determine the Qcr serum and reference range creatinine concentrations, 913 healthy elderly patients (452 males and 461 females) undergoing routine examinations at clinical laboratories were studied. Creatinine concentration reference intervals were divided into 3 age groups, namely: 60-69 years, 70-79 years, and >80 years. The median and percentiles p2.5 (lower reference limit/LRL) and p97.5 (upper reference limit/URL) were determined by the study. The study determined the Qcr serum creatinine and reference values for the elderly, stratified by age and sex. There were no significant differences observed in creatinine level across the age group, either in males or females. Males exhibited higher creatinine compared to females (p <0.05). These recently developed, age and sex stratified Qcr values are an invaluable tool for clinical laboratories, enabling more precise, tailored care for elderly patients with renal issues and enabling clinicians to more accurately assess geriatric renal function.