Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Jurnal Kedokteran Meditek
Ciptono, Freddy
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Hubungan Kadar Asam Urat terhadap Rasio Netrofil-Limfosit pada Pasien Medical Check-Up di Klinik X Jakarta Pusat Christanto, Dionisius Benito Prayoga; Ciptono, Freddy
Jurnal Kedokteran Meditek Vol 30 No 3 (2024): SEPTEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v30i3.3272

Abstract

Asam urat adalah produk hasil katabolisme purin. Diet tinggi purin dapat meningkatkan risiko terjadinya peningkatan kadar asam urat tubuh. Gangguan dalam proses produksi dan ekskresi asam urat, serta kombinasi keduanya dapat memicu terjadinya hiperurisemia. Hiperurisemia dapat menginduksi terbentuknya reactive oxygen species yang berperan dalam inflamasi. Penelitian terdahulu menemukan hubungan antara rasio netrofil-limfosit (NLR) dan serum uric acid, terutama pada periode serangan asam urat. Hal tersebut akan diuji melalui metode regresi linear dalam penelitian ini. Penelitian ini bertujuan untuk meneliti peristiwa inflamasi yang disebabkan oleh asam urat melalui rasio netrofil-limfosit. Penelitian dilakukan dengan metode cross-sectional dan menggunakan data rekam medis medical check-up pasien di Klinik X tahun 2023 yang diperoleh secara acak. Pasien dewasa (19—44 tahun) sebanyak 88 orang dianalisis menggunakan aplikasi SPSS dengan metode regresi linear untuk mengetahui korelasi antarvariabel tersebut. Terdapat hubungan yang signifikan secara statistik antara kadar asam urat terhadap rasio netrofil-limfosit (p < 0,050) dan diperoleh suatu persamaan y= 1,320 + 0,071X. Berdasarkan data rekam medis medical check-up Klinik X Jakarta Pusat tahun 2023, terdapat hubungan antara kadar asam urat dengan NLR secara statistik serta persamaan menunjukkan nilai positif yang menunjukkan bahwa asam urat yang tinggi akan memiliki NLR yang tinggi.
Correlation of Uric Acid Levels with Lipid Profile among MCU Patients Hidayah, Aghnia; Ciptono, Freddy
Jurnal Kedokteran Meditek Vol 31 No 1 (2025): JANUARI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i1.3297

Abstract

Introduction: Uric acid (C5H4N4O3) is a product of purine degradation and can act as a pro-oxidant substance because of the formation of ROS through the enzymatic activity of xanthine oxidase. Previous research has shown that uric acid can affect lipid metabolism in the body. Purpose: This study aims to explore the relationship between lipid profiles in MCU patients and uric acid levels. This study employs a cross-sectional design, and we will analyze the data using linear regression. Methods: This study is an observational analytic study without intervention, using a cross-sectional study design. The research data came from secondary data, especially the medical records of MCU patients. Researchers selected the study sample using a random sampling technique. The study uses 86 secondary data samples. Results: Linear regression analysis reveals a significant positive correlation between uric acid and triglycerides (p-value < 0.001 and r = 0.464), total cholesterol (p-value = 0.018 and r = 0.255), and LDL (p-value = 0.011 and r = 0.273). A significant negative correlation exists between uric acid levels and HDL (p-value < 0.001 and r = 0.477). Increased uric acid levels are associated with higher levels of TG, TC, and LDL, as well as a decrease in HDL levels. The average levels of LDL and total cholesterol are 140.27 mg/dl and 206.66 mg/dl, respectively, which are at the high threshold, while all other variables are within normal limits. Conclusion: This study concludes that uric acid levels and lipid profile levels are significantly related
Co-Authors Christanto, Dionisius Benito Prayoga Hidayah, Aghnia