Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal JPBIO (Jurnal Pendidikan Biologi)
Ferta Liza Putri
Department of Biology, Faculty of Mathematics and Natural Sciences, Sriwijaya University
Education

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Lansium domesticum metabolites interfere with digestive enzyme function in the rice weevil sitophilus oryzae Yadi Oktariansyah; Ferta Liza Putri; Yuniar Harvianti; Eva Musifa
JPBIO (Jurnal Pendidikan Biologi) Vol 11, No 1 (2026): April 2026
Publisher : STKIP Persada Khatulistiwa Sintang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31932/jpbio.v11i1.6212

Abstract

Pectin methylesterase (PME) plays a key role in polysaccharide digestion in the rice weevil Sitophilus oryzae, making it a potential molecular target for pest control. This study employed structure-based in silico analysis to evaluate selected metabolites of Lansium domesticum as PME inhibitors. Representative compounds were chosen according to predicted interference mechanisms and docked into the validated catalytic site. All complexes showed structural stability, while interaction patterns revealed six inhibition modes: competitive mimicry, catalytic disruption, orientation interference, channel blocking, polymer mimicry, and interfacial modulation, whereas polyphenols and glycosides produced the strongest interference. The findings indicate that L. domesticum metabolites can disrupt digestive enzymatic processes through multiple complementary pathways, supporting their potential development as biologically derived pest management agents.
Co-Authors Eva Musifa Yadi Oktariansyah Yuniar Harvianti