Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Journal Research of Social Science, Economics, and Management
Yulistiani Yulistiani
Universitas Airlangga
Environmental Science Materials Science & Nanotechnology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
The Impact of Polypharmacy on Medication Problems and Clinical Outcomes in Patients with Stage 5 Chronic Kidney Disease Undergoing Hemodialysis: A Narrative Review Primatia Adrini Hapsari; Yulistiani Yulistiani; Githa Fungie Galistiani
Journal Research of Social Science, Economics, and Management Vol. 5 No. 12 (2026): Journal Research of Social Science, Economics, and Management
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jrssem.v5i12.1581

Abstract

Patients with stage 5 chronic kidney disease (CKD) who undergo routine hemodialysis (HD) often receive a complex treatment regimen (polypharmacy) to control comorbidities. This condition increases susceptibility to drug-related problems (DRPs) due to pharmacokinetic and pharmacodynamic changes after nephron damage. This narrative review aims to evaluate the impact of polypharmacy on the incidence of drug problems (DRPs) and its implications on various clinical outcomes, quality of life, and cost burden in stage 5 CKD patients with routine HD. This writing used a narrative review method through searching literature from various scientific data sources such as Google Scholar, PubMed, and Scince Direct, as well as national journals with a publication time span of the last 5-10 years. Literature analysis showed that polypharmacy was strongly correlated with a high incidence of moderate to major drug interaction potential (DDI) (49–89%) and drug side effect multiplication (ADRs). The use of drugs without proper dosage adjustment to the dialysis circuit triggers therapy failure. Monitoring of therapeutic outputs has been proven to integrate the dimensions of clinical data, laboratory biomarkers, economic aspects, and drug burden reduction through deregulation. Polypharmacy in ESRD-HD patients poses massive clinical and financial problems. The active involvement of clinical pharmacists through treatment reconciliation and selection of drug types with safe non-renal elimination is crucial to minimize the risk of toxicity, optimize clinical outcomes, and improve patients' quality of life.
Narrative Review: Evaluasi Penggunaan Antibiotika Empiris pada Pasien Pneumonia Dewasa: Narrative Review: Evaluation of Empirical Antibiotic Use in Adult Pneumonia Patients Farah Nurul Hidayah; Yulistiani Yulistiani; Elza Sundhani
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 23 No. 01 Juli 2026
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pneumonia merupakan salah satu penyakit infeksi saluran pernapasan bawah yang paling sering terjadi. Pada pneumonia terjadi peradangan pada parenkim paru yang disebabkan oleh mikroorganisme. Di Indonesia, menurut Riset Kesehatan Dasar (Riskesdas) tahun 2022, terdapat 310.871 kasus pneumonia. Jumlah ini diperkirakan akan terus meningkat setiap tahun. Bakteri patogen penyebab pneumonia yang paling umum adalah Mycobacterium pneumoniae, Streptococcus pneumoniae, dan Haemophilus influenzae, sedangkan virus patogen penyebab pneumonia tersering adalah rhinovirus, virus influenza, dan virus parainfluenza. Dalam pembuatan narrative review ini, dimulai dengan melakukan proses pencarian artikel/jurnal di beberapa database seperti Scopus dan Google Scholar menggunakan kata kunci Community Pneumonia, Empirical Antibiotic, DDD, Gyssens, dan Clinical Outcome. Artikel/jurnal penelitian dipublikasikan dalam kurun waktu 5 tahun terakhir (2020-2025). Analisis kuantitatif antibiotika dengan metode ATC/DDD menunjukkan bahwa penggunaan antibiotika empiris terbesar adalah Ceftriaxone (golongan sefalosporin generasi 3), Levofloxacin (golongan fluorokinolon), dan Moxifloxacin (golongan kinolon). Analisis kualitatif antibiotika menggunakan alur Gyssens dan PPAB, di mana ketepatan pemberian antibiotika hasilnya bervariasi: ada yang persentase ketepatannya lebih besar, ada yang persentase ketepatannya lebih kecil. Semakin bertambah usia pasien, akan semakin meningkat risiko terkena penyakit pneumonia, dan penderita pneumonia dewasa didominasi oleh laki-laki. Adapun hubungan rasionalitas penggunaan antibiotika empiris dengan luaran klinis, hasilnya ada yang tidak berpengaruh pada outcome klinis dan ada hasil yang menunjukkan tingkat perbaikan klinis 70,7% lebih tinggi pada penggunaan antibiotika sesuai pedoman yang berpengaruh terhadap outcome klinis pasien.
Co-Authors Farah Nurul Hidayah Githa Fungie Galistiani Primatia Adrini Hapsari Sundhani, Elza