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Sofa Fajriah
Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Cibinong Science Center Complex – BRIN, Cibinong 16911, Bogor, West Java, Indonesia
Astronomy Chemistry Earth & Planetary Sciences Mathematics Physics

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Penta- and Tetra-cyclic Triterpenoids from Aglaia cucullata Stembark and Cytotoxicity against Cancer and Normal Cells Kindi Farabi; Wahyu Safriansyah; Desi Harneti; Hadi Kuncoro; Sofa Fajriah; Unang Supratman
Journal of Mathematical and Fundamental Sciences Vol. 57 No. 2 (2025)
Publisher : Directorate for Research and Innovation (DRI) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2025.57.2.1

Abstract

Three triterpenoid compounds, belonging to the penta- and tetracyclic groups, were successively isolated from the stembark of Aglaia cucullata and identified as b-amyron (1), dammaradienon (2), and cabralealactone (3). After extensive extraction, chromatographic separation and purification, compounds 1 to 3 were gained. Spectroscopic analysis in addition to HRMS, FTIR, 1D and 2D NMR analysis were utilized to determine the chemical structure. After that, compounds 1 to 3 were tested against breast cancer, melanoma as well as normal kidney cells (MCF-7, B16-F10, and CV-1, respectively). The resulted cytotoxicity test revealed that compound 1 had the best cytotoxicity against all cells compared with the other isolated compounds. This result suggests that the pentacyclic triterpenoid core in compound 1 increases cytotoxicity compared with a tetracyclic skeleton.
Co-Authors Desi Harneti Hadi Kuncoro Kindi Farabi Unang Supratman Wahyu Safriansyah