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All Journal JOURNAL LA MEDIHEALTICO Healthy Tadulako Journal (Jurnal Kesehatan Tadulako)
Asrini Safitri
Department of Clinical Nutrition, Faculty of Medicine, Universitas Muslim Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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The Effect of Resveratrol on Fasting Blood Glucose Levels as a Parameter of Type 2 Diabetes Mellitus Dinda Briliani Rahman; Rachmat Faisal Syamsu; Asrini Safitri
Journal La Medihealtico Vol. 6 No. 5 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i5.2714

Abstract

characterized by chronic hyperglycemia, insulin resistance, and increased oxidative stress. Resveratrol, a naturally occurring polyphenolic compound, has been widely investigated for its potential antidiabetic effects in preclinical studies, although findings across animal models remain inconsistent and require systematic synthesis. This study aimed to review and synthesize evidence on the effects of resveratrol on glycemic regulation, insulin signaling, lipid metabolism, and oxidative stress in animal models of T2DM. The review followed PRISMA 2020 guidelines. Electronic searches were conducted in PubMed, Scopus, Sinta, and Google Scholar for articles published between 2019 and 2024. Eligible studies were original experimental investigations employing animal models of T2DM with resveratrol as the primary intervention. Owing to heterogeneity in study designs and outcome measures, data were synthesized using a qualitative narrative approach. Seven studies met the inclusion criteria. Overall, resveratrol administration was associated with reductions in fasting blood glucose, improvements in insulin sensitivity, and modulation of key insulin signaling pathways, particularly the PI3K Akt FOXO1 axis. Most studies also reported favorable effects on lipid profiles and reductions in oxidative stress markers. Although one study reported no significant improvement in glycemic indices, the overall pattern indicated consistent positive metabolic effects. This systematic review suggests that resveratrol exerts antidiabetic effects in animal models of T2DM by improving glycemic control, insulin signaling, lipid metabolism, and oxidative stress regulation. However, further well designed studies are needed to clarify dose response relationships and facilitate clinical translation.
Nutritional Status Before and After Routine Deworming Medication Intake Among Children Aged 6–12 Years in the Working Area of Karuwisi Public Health Center Nur Agustini Halim; Nurfachanti Fattah; Andi Husni Esa Darussalam; Asrini Safitri; Nur Fadhillah Khalid
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 12 No. 3 (2026)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/8sk79k25

Abstract

Background: Soil transmitted helminth infections remain relevant to child health and nutrition in Indonesia, and local evidence supports continued attention to hygiene, deworming, and nutritional assessment. Objective: This study aimed to describe nutritional status before and after routine deworming among children aged 6–12 years in the Karuwisi Public Health Center working area and to assess concordance between the two recorded nutritional status classifications. Methods: This observational analysis included 67 students from SD Inpres Karuwisi I who routinely received deworming medication twice per year. Nutritional status was classified using sex and age specific BMI percentiles from the 2000 CDC reference. Proportions with 95% confidence intervals were reported. Spearman Rho assessed ordinal concordance between the recorded before and after categories and was not interpreted as a treatment effect. Results: Normal nutritional status increased descriptively from 43.3% to 65.7%, while underweight decreased from 40.3% to 16.4%. The recorded classifications were strongly correlated (p = 0.771; p < 0.001). Conclusion: The post deworming distribution was more favorable among routine users, but causality cannot be inferred because there was no non routine comparison group, parasitological confirmation, or adjustment for major nutritional confounders.
Co-Authors Andi Husni Esa Darussalam Dinda Briliani Rahman Nur Agustini Halim Nur Fadhillah Khalid Nurfachanti Fattah Rachmat Faisal Syamsu