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Erlyn Limoa
Department Psychiatry, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology

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Adjunctive Statin Therapy on Cholesterol and Clinical Symptoms in Schizophrenia Treated with Risperidone Irma Santy; Andi Ummulkhair Pawallangi Irawan; Erlyn Limoa; Fanny Wijaya; Ilma Khaerina Amaliyah Bakhtiar; Muhammad Alim Jaya
UMI Medical Journal Vol 10 No 2 (2025): UMI Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/7y6f9607

Abstract

Background: Schizophrenia is associated with the metabolic side effects of atypical antipsychotics, such as hypercholesterolemia. Objective: To evaluate the effect of adjuvant statin therapy on total cholesterol levels and clinical symptoms in patients with schizophrenia treated with risperidone. Methods: This randomized clinical trial was conducted on 36 patients with schizophrenia at RSKD Dadi, South Sulawesi. The subjects were randomized into risperidone-only and risperidone plus statin groups. Results: Statin adjuvant therapy reduced total cholesterol levels and improved clinical symptoms (PANSS scores) compared to the control group. Conclusion: Adjuvant statin therapy is potentially beneficial in reducing cholesterol levels and improving clinical outcomes in patients with schizophrenia receiving risperidone.
Co-Authors Andi Ummulkhair Pawallangi Irawan Fanny Wijaya Ilma Khaerina Amaliyah Bakhtiar Irma Santy Muhammad Alim Jaya