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All Journal Biodiversitas Journal of Biological Diversity
CHAIRUL CHAIRUL
Bidang Botani, Pusat Penelitian Biologi, Lembaga Ilmu Pengetahuan Indonesia (LIPI), Cibinong-Bogor 16911
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology

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The effect of pauh kijang (Irvingia malayana Oliv ex. A. Benn) in decreasing parasitemia percentage in mice infected with Plasmodium berghei PRAPTIWI PRAPTIWI; CHAIRUL CHAIRUL
Biodiversitas Journal of Biological Diversity Vol. 9 No. 2 (2008)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d090204

Abstract

This study was conducted to determine the influence of pauh kijang (Irvingia malayana Oliv.) stem bark ethanol extract in decreasing parasitemia in mice infected with Plasmodium berghei. Mice were divided into 6 groups as treatments: (1) negative control (CMC), pauh kijang ethanol extract with the concentration of (2)1, (3)10, (4)100, (5) 1000 mg/kg BW, and (6) quinine as positive control. The result showed that meridian effective dose (ED50) of pauh kijang ethanol extract was 36.95 mg/kg BW. Treatment of 100 mg/kg BW lowered parasitemia level by 63.8%, and this treatment did not give significant different (P>0.05) compared to positive control. The result suggests that pauh kijang ethanol extract had antiplasmodial activity since this extract reduces parasitemia more than 30%.© 2008 Jurusan Biologi FMIPA UNS SurakartaKey words: Irvingia malayana, antimalarial, malaria, ED50, plasmodium
Co-Authors PRAPTIWI PRAPTIWI