Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Biodiversitas Journal of Biological Diversity
SUNARNO SUNARNO
Department of Bacteriology, Center for Biomedical and Basic Technology of Health, National Institute of Health Research and Development. Jl. Percetakan Negara 29, Jakarta 10560
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Short Communication: Investigation of Diphtheria in Indonesia: dtxR and tox genes analysis of Corynebacterium diphtheriae collected from outbreaks YUANITA MULYASTUTI; SIWIPENI I. RAHAYU; SUNARNO SUNARNO; EDDY B. WASITO
Biodiversitas Journal of Biological Diversity Vol. 18 No. 2 (2017)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d180249

Abstract

Mulyastuti Y, Rahayu SI, Sunarno S, Santoso S, Wasito EB. 2017. Short Communication: Investigation of Diphtheria in Indonesia: dtxR and tox genes analysis of Corynebacterium diphtheriae collected from outbreaks. Biodiversitas 18: 784-787. Diphtheria outbreaks have sporadically occurred in Indonesia recently. It is suspected that toxin profile changes play an important role in vaccine efficacy and the occurrence of outbreaks. This study aimed to investigate the genetic changes of dtxR and tox genes in Corynebacterium diphtheria in Indonesia. Four C. diphtheriae toxigenic isolates circulating in current outbreak area were analyzed by comparing DNA sequences of their dtxR and tox genes to those of the PW8 vaccine strain. Among the four isolates, three point mutations were detected in dtxR gene while three other point mutations were detected in the tox gene. All six were silent mutations, suggesting that the diphtheria toxin is highly conserved at the amino acid sequence level, and indirectly indicating that the vaccine remains appropriate. Genetic variation in dtxR and tox genes of C. diphtheriae isolates from the recent outbreaks in Indonesia was detected.
Co-Authors EDDY B. WASITO SIWIPENI I. RAHAYU YUANITA MULYASTUTI