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All Journal Biodiversitas Journal of Biological Diversity
ARDHINI RIN MAHARNING
Faculty of Biology, Universitas Jenderal Soedirman. Jl. Dr. Soeparno 63, Purwokerto Utara, Banyumas 53122, Central Java, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology

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Compounds detection and inhibition activity of chloroform and ethyl acetate extracts of Schizophyllum commune on some cancer cell types Nuraeni Ekowati; ARIS MUMPUNI; NUNIEK INA RATNANINGTYAS; ARDHINI RIN MAHARNING
Biodiversitas Journal of Biological Diversity Vol. 21 No. 12 (2020)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d211251

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Abstract. Ekowati N, Mumpuni A, Ratnaningtyas NI, Maharning A. 2020. Compounds detection and inhibition activity of chloroform and ethyl acetate extracts of Schizophyllum commune on some cancer cell types. Biodiversitas 21: 5865-5871. Schizophyllum commune Fr.is a potential fungus utilized as a drug, including a cancer drug expectant. In Indonesia, the fungus' capability to suppress the growth of certain types of cancer cells has not been widely reported. The purposes of this study were (i) to determine the bioactive compound group from S. commune using organic solvents chloroform and ethyl acetate, (ii) to determine the IC50 values ??of S. commune bioactive compounds using cancer cell lines HeLa, MCF7, T47D and WiDr, (iii) to find out the mechanism of apoptosis. The research was carried out experimentally using a pure culture of four types of cancer cell lines. Anticancer activity test was conducted by a cytotoxic test using MTT [3- (4,5- dimethylthiazol -2-yl) -2.5-diphenyl tetrazolium bromide], and apoptosis test. Data analysis was performed with linear regression analysis, and the apoptosis test was analyzed descriptively. The results showed that the bioactive compounds produced by S. commune are alkaloids, terpenoids, and flavonoids. S. commune bioactive compounds potentially inhibit the four cancer cell lines used with IC50 values ??ranging from 5.44 to 420.48 ug/mL. Best result was obtained from S. commune extract of chloroform in T47D cells with IC50 = 5.44 ug/mL and are able to induce apoptosis.
Nematode functional traits and community structure change from river to the terrestrial border in Segara Anakan Mangrove, Indonesia ARDHINI RIN MAHARNING; ERWIN RIYANTO ARDLI; ROMANUS EDY PRABOWO
Biodiversitas Journal of Biological Diversity Vol. 24 No. 4 (2023)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d240459

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Abstract. Maharning AR, Ardli ER, Prabowo RE. 2023. Nematode functional traits and community structure change from river to the terrestrial border in Segara Anakan Mangrove, Indonesia. Biodiversitas 24: 2434-2446. We intended to explore the spatial distribution of nematode functional traits and community structure in Segara Anakan Mangrove, Indonesia. Samples were retrieved from 14 stations, extending from the river to the area adjacent to terrestrial forest. We used taxonomic and functional trait identification, covering body shape, length, tail shape, feeding type, and life history as independent traits, and combined traits by collecting traits describing individual nematodes. The principal component analysis suggested that predatory or omnivorous or long-size nematodes mainly inhabited stations adjacent to the terrestrial forest but were unclear for the mid-stations. There were 29 combined traits and 38 genera of nematodes observed. The detrended correspondence analysis revealed that nematode compositional changes from the river to the terrestrial adjacent area were clearer for the combined traits and nematode genera. Seven combined traits and 12 genera inhabited only the particular stations of the study site. The common nematodes were slender, 1-2 mm long, elongated filiform tails, non-selective deposit feeders, and very tolerant to pollutants, which lived in almost all stations (92.86%). The genus relative abundance (>10%) included Anoplostoma, Eubostrichus, and Chromadorina. The results suggest that distance from the river might regulate the habitability of nematodes, in which nematode functional traits play roles.
Co-Authors ARIS MUMPUNI ERWIN RIYANTO ARDLI NUNIEK INA RATNANINGTYAS Nuraeni Ekowati ROMANUS EDY PRABOWO