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RAVINDRA ADE
Department of Biotechnology, Sant Gadge Baba Amravati University. Amravati 444602, Maharashtra, India
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Multiple shoot formation in Gloriosa superba: A rare and endangered Indian medicinal plant RAVINDRA ADE; MAHENDRA RAI
Nusantara Bioscience Vol. 3 No. 2 (2011)
Publisher : Smujo International

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/nusbiosci/n030203

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Abstract. Ade R, Rai M. 2011. Multiple shoot formation in Gloriosa superba: A rare and endangered Indian medicinal plant. Nusantara Bioscience 3: 68-72. We report in vitro growth of callus and multiple shoots and standardized the culture conditions for Gloriosa superba. The main aim of the present study was to evaluate the effect of different growth media with different hormonal concentrations on callus induction and multiple shoot formation in Gloriosa superba. The results indicated that MS medium supplemented with 2,4-D 4.52 mM and BAP 13.30 mM promoted the formation of the maximum number of shoots compared to IAA, IBA and with Gamborg B5 medium supplemented with kinetin, IBA and BAP were found to be superior.
Review: Colchicine, current advances and future prospects RAVINDRA ADE; MAHENDRA KUMAR RAI
Nusantara Bioscience Vol. 2 No. 2 (2010)
Publisher : Smujo International

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/nusbiosci/n020207

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Abstract. Ade R, Rai MK. 2010. Colchicine, current advances, and future prospects. Nusantara Bioscience 2: 90-96. Colchicine is a toxic natural compound and secondary metabolite commonly produced by plants like Colchicum autumnale and Gloriosa superba. It is originally used to treat rheumatic complaints, especially gout, and still finds its uses for these purposes today despite dosing issues concerning its toxicity. It is also prescribed for its cathartic and emetic effects. Initially, oral colchicine has not been approved as a drug by U.S. Food and Drug Administration (FDA). But now FDA approved colchicine as a drug for some disorders. Colchicine's present medicinal use is in the treatment of gout and familial Mediterranean fever. It is also being investigated for its use as an anticancer drug. In neurons, axoplasmic transport is disrupted by colchicine. Due to all the pharmacological application of colchicine, there is an urgent need to enhance the properties and increase the production of colchicine with the help of in vitro technologies. The present review is mainly focused on the chemistry of colchicine, its medicinal uses, and toxicity.
Co-Authors MAHENDRA KUMAR RAI MAHENDRA RAI