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All Journal Majalah Kedokteran Neurosains
Ardefiyenti, Basjiruddin A, Jamsari MP
Neurona Majalah Kedokteran Neuro Sains
Neuroscience

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HUBUNGAN POLIMORFISME GEN SCN1A DENGAN RESPONS TERHADAP OBAT ANTI EPILEPSI FENITOIN DAN KARBAMAZEPIN Ardefiyenti, Basjiruddin A, Jamsari MP
NEURONA Vol 29 No. 4 Agustus 2012
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

INTRODUCTION PHENYTOIN AND CARBAMAZEPINE ARE THE FIRST LINE AED ANTIEPILEPTIC DRUG THAT ARE WIDELY USED IN THE TREATMENT OF EPILEPSY PHENYTOIN AND CARBAMAZEPINE WORKS BY BLOCKING SODIUM CHANNELS SCN1A GENE IS A GENE THAT CODES THE FORMATION OF THE SODIUM CHANNEL THE PRESENCE OF FUNCTIONAL POLYMORPHISMS WILL CAUSE DISRUPTION TO THE SODIUM CANAL CAUSING AED DOES NOT WORK TO OVERCOME SEIZURES THIS STUDY PURPOSED TO DETERMINE THE TYPE OF SCN1A GENE POLYMORPHISM AND RESPONSE TO AED
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