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All Journal Jurnal Kedokteran Diponegoro
Diaz Alifarizki Zuvarcan
Faculty of Medicine, Sebelas Maret University
Medicine & Pharmacology

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RECURRENT MALIGNANT PERIPHERAL NERVE SHEATH TUMOR OF THE LEFT FEMUR POST MULTIMODAL THERAPY IN 61 YEARS OLD MALE: A CASE REPORT Diaz Alifarizki Zuvarcan; Christopher Bryan; Sri Marwanta
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 3 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i3.53468

Abstract

Background: Malignant peripheral nerve sheath tumors (MPNST) are rare, aggressive soft tissue sarcomas with a high rate of recurrence and metastasis. Sporadic MPNSTs, especially in older adults without neurofibromatosis type 1, present additional diagnostic and therapeutic challenges. Case Presentation: We report a 61-year-old male with a recurrent sporadic MPNST of the left femur. Over six years, he underwent three surgical excisions, radiotherapy, and two lines of chemotherapy. Despite initial partial response, the disease progressed with pulmonary metastases. Histopathology revealed spindle cell sarcoma with lymphovascular and skeletal muscle invasion. Conclusion: This case highlights the difficulty of achieving durable control in recurrent MPNST despite multimodal therapy. It underscores the importance of vigilant follow-up, individualized treatment plans, and supportive care in advanced disease settings.
Co-Authors Christopher Bryan Sri Marwanta