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All Journal International Journal of Health, Engineering and Technology
Annie Rahmatillah
Duta Bangsa University
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Hair Tonic Formulation of Green Spinach Leaf Extract (Amaranthus viridis L.) as a Hair Growth Agent for New Zealand Rabbits (Oryctolagus cuniculus) Shinta Putri Rahmawati; Septian Maulid Wicahyo; Annie Rahmatillah
International Journal of Health Engineering and Technology Vol. 4 No. 5 (2026): IJHESS JANUARY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i5.558

Abstract

Hair loss can lead to baldness, and many commercial hair tonics contain synthetic chemicals with potential side effects. This study explores the use of natural ingredients, specifically green spinach leaf (Amaranthus viridis) extract, as an alternative. Green spinach leaves are rich in flavonoids, tannins, saponins, and antioxidants, which are known to stimulate hair growth. The research aims to evaluate the hair growth activity of green spinach leaf extract on New Zealand rabbits (Oryctolagus cuniculus), assess the physical quality of hair tonic formulations at three concentrations (5%, 10%, 15%), and determine the most effective formula. The study used a quantitative, descriptive, and experimental approach. Extracts were obtained via maceration with 96% ethanol and formulated into hair tonics. Rabbits were divided into six groups: untreated, positive control, negative control, and three treatment groups (F1, F2, F3). Phytochemical screening confirmed the presence of flavonoids, saponins, and tannins. Physical stability tests showed all formulations were stable. Statistical analysis (One-Way ANOVA and Post Hoc Tukey) revealed significant differences in hair growth between treatment and negative control groups, with the 15% formula (F3) yielding the highest average hair growth (10.67 mm).
Formulation And Antioxidant Activity Testing Of Ethanol Extract Moisturizing Gel From Kesum Leaves (Polygonum Minus Huds.) Using The DPPH (2,2-Diphenyl-1-Picrylhydrazyl) Method Windy Marcella; Bangkit Riska Permata; Annie Rahmatillah
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.684

Abstract

Free radicals are unstable molecules that can cause cell damage and play a role in premature aging and various skin disorders. One way to inhibit the effects of free radicals is through the use of topical preparations containing antioxidants. Kesum leaves (Polygonum minus Huds) are known to contain bioactive compounds, particularly flavonoids and phenolics, which have the potential to act as natural antioxidants. This study aims to formulate kesum leaf ethanol extract into a moisturizing gel preparation and evaluate its physical quality and antioxidant activity using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. This study was an experimental study with variations in the concentration of kesum leaf ethanol extract, namely F1 (1%), F2 (2%), and F3 (3%). The evaluation of the physical quality of the gel included organoleptic testing, homogeneity, pH, Viscosity and spreadability. Antioxidant activity was expressed as the IC₅₀ value. The results showed that all gel formulations met the physical quality requirements for preparations. The IC₅₀ values of the gel preparations in F1, F2, and F3 were 169.556 ppm, 150.759 ppm, and 125.396 ppm, respectively, while the positive control showed an IC₅₀ value of 44.792 ppm. An increase in the concentration of kesum leaf ethanol extract in the gel formulation showed a tendency to increase antioxidant activity. Formula F3 had the best antioxidant activity among the gel formulations tested. Thus, kesum leaf ethanol extract has potential as an antioxidant agent.
Co-Authors Bangkit Riska Permata Septian Maulid Wicahyo Shinta Putri Rahmawati Windy Marcella