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All Journal International Journal of Health, Engineering and Technology
Septian Maulid Wicahyo
Duta Bangsa University, Surakarta
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Memory Activity Test Of Ethanol Extract Of Oil Palm Leaves (Elaeis Guineensis Jacq.) On White Mice (Mus Musculus) With Radial Arm Maze Method Nadia; Bagas Ardiyantoro; Septian Maulid Wicahyo
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.607

Abstract

Memory loss is a cognitive disorder in which oxidative stress is one of the main contributing factors. Palm leaves oil (Elaeis guineensis Jacq.) contains flavonoids and antioxidants that are believed to improve memory. This study aims to determine whether oil palm leaf extract can improve memory activity in mice and determine the most effective dosage. This study was a pure experimental study with 25 mice divided into five groups, namely negative control (CMC Na 1%), positive control (Ginkgo biloba), and treatment groups with ethanol extracts of oil palm leaves at doses of 100 mg/kgBW, 200 mg/kgBW, and 300 mg/kgBW. The mice were induced with 10% alcohol and then given treatment for 7 days. Memory activity was tested using the Radial Arm Maze method, with parameters measured including latency time and error rate. The data obtained were then analyzed using SPSS, including normality and homogeneity tests, Anova, and followed by the Tukey test. The results showed that doses of palm leaf extract (Elaeis guineensis jacq.) of 100 mg/kgBW, 200 mg/kgBW, and 300 mg/kgBW had an effect on the memory of mice. The effective dose for improving memory in the T1-T2 latency time difference was 200 mg/kgBW and 300 mg/kgBW with a P value > 0.05, which was not significantly different from the positive control, and the T1-T2 error rate difference was 100 mg/kgBW, 200 mg/kgBW, and 300 mg/kgBW, with a P value > 0.05, showing no significant difference from the positive controls. This proves that oil palm leaf extract can enhance memory activity in mice.
Identification Formula For Hydroquinone Compound Content In Bulk Body Lotion Cosmetic Preparations Sold On E-Commerce Ananda Saputra; Septian Maulid Wicahyo; Siwi Hastuti
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.608

Abstract

The distribution of skin-whitening cosmetics, especially body lotions, through e-commerce platforms is increasing and may contain hazardous ingredients such as hydroquinone. Hydroquinone is a compound that is prohibited for use in cosmetics because it can cause side effects such as dark spots on the skin, allergic reactions, irritation, brain damage, and cancer. This study aims to identify and determine the levels of hydroquinone in body lotion cosmetics sold on e-commerce platforms. This is an observational study with a descriptive approach. A total of three body lotion samples were analyzed qualitatively using a color reaction test with FeCl₃ reagent and thin-layer chromatography (TLC) method, and analyzed quantitatively using ultraviolet-visible spectrophotometry (UV-Vis). The hydroquinone content was determined based on the calibration curve of the standard solution at the maximum wavelength. The results showed that two of the three samples tested positive for hydroquinone in the qualitative test. Quantitative analysis showed that the hydroquinone content in sample 1 was (70.48 ± 0.0044)% and in sample 3 was (67.88 ± 0.0021)%. These levels do not meet cosmetic safety requirements according to the regulations of the Food and Drug Supervisory Agency (BPOM). It can be concluded that there are still body lotions circulating on e-commerce platforms that contain high levels of hydroquinone, so stricter supervision and increased public education regarding cosmetic safety are needed.
Determination Of Sun Protective Factor (SPF) Values In N-Hexane, Ethyl Acetate, And Water Fractions Of Ethanol Extract Of Tamarind Eggplant (Solanum Lasiocarpum Dunal.) Peel With UV-VIS Spectrophotometry Method Natalia Riska Angelinda; Septian Maulid Wicahyo; Alfina Nurrahman
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.685

Abstract

Excessive UV exposure causes skin damage, so natural sunscreen alternatives are needed. This experimental descriptive study aims to identify and measure the Sun Protection Factor (SPF) value of ethanol extract and n-hexane, ethyl acetate, and water fractions from Solanum lasiocarpum Dunal fruit peel in vitro using UV-Vis spectrophotometry. The population of the entire skin simplicia from Tanjung Hulu, Pontianak; a sample of 500 g of powder (mesh 40) was extracted and fractionated. Instruments include a Thermo Scientific UV-Vis spectrophotometer (290-320 nm), rotary evaporator, TLC plate; SPF was calculated using the Mansur equation and Lambert-Beer validation linear regression. The results showed the highest SPF of ethyl acetate fraction (36.97 at 500 ppm, high category), while the ethanol extract (9.32), n-hexane (6.71), and water (6.76) were low. Phytochemical screening was positive for alkaloids, terpenoids, phenolics, and flavonoids. In conclusion, the ethyl acetate fraction has optimal potential for the development of sunscreen cosmetics.
Co-Authors Alfina Nurrahman Ananda Saputra Bagas Ardiyantoro Nadia Natalia Riska Angelinda Siwi Hastuti