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All Journal International Journal of Health, Engineering and Technology
Danny Ernest Jonas Luhulima
Department of Clinical Pathology, Medical Faculty, Universitas Kristen Indonesia, Indonesia
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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D-Dimer In Pregnancy Danny Ernest Jonas Luhulima; Batara Imanuel Sirait
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.696

Abstract

D-dimer is a fibrin degradation product that serves as a vital biomarker in the fibrinolytic system. This review aims to examine the role and mechanism of D-dimer during pregnancy and its measurement methods. The method used is a literature review of clinical studies and references related to hemostasis in pregnancy. Results show that pregnancy physiologically increases coagulation activity as a natural mechanism to prevent hemorrhage during delivery. Increased D-dimer levels are found in 27% of first-trimester pregnancies, 87% in the second trimester, and 100% in the third trimester. Pathological conditions such as preeclampsia, eclampsia, and venous thromboembolism (VTE) risks are closely linked to significant surges in D-dimer levels. While ELISA remains the gold standard for D-dimer testing, immunoturbidimetric and immunofiltration methods are more commonly used due to their speed and efficiency. In conclusion, although D-dimer levels naturally rise during pregnancy, monitoring this parameter is crucial for predicting medical emergencies like disseminated intravascular coagulation (DIC) to reduce maternal mortality rates.
Co-Authors Batara Imanuel Sirait