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All Journal International Journal of Health, Engineering and Technology
Aurellia Saraswati Winahyu Naiaputri
a:1:{s:5:"en_US";s:21:"Universitas Airlangga";}
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Cost-Effectiveness Analysis Of Biomarker-Based And Risk-Based Screening In Early Detection Of Preeclampsia: Systematic Review Aurellia Saraswati Winahyu Naiaputri
International Journal of Health Engineering and Technology Vol. 5 No. 1 (2026): IJHET MAY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i1.753

Abstract

Preeclampsia is one of the leading causes of maternal morbidity and mortality, especially in developing countries. Evaluation of the cost-effectiveness of first-trimester screening is essential to ensure accurate and efficient interventions. The objective of this review is to examine and compare the cost-effectiveness between biomarker-based preeclampsia screening and maternal risk-based screening in the first trimester of pregnancy. This study used a systematic review method based on the PRISMA guidelines. Articles searched through PubMed and ScienceDirect with a range of 2020–2025. Quality assessment using the CHEERS Checklist. Five studies were included in this review. All studies show that first-trimester preeclampsia screening is a cost-effective, even cost-saving strategy, especially when combined with early aspirin. Biomarker-based screening and risk algorithms are more cost-efficient than conventional screening. These results can be the basis for the formulation of maternal health policies in Indonesia. Preeclampsia, first trimester screening, cost-effectiveness, biomarkers.
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