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p-Index From 2021 - 2026
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All Journal International Journal of Health, Engineering and Technology
Saeful Amin Saeful Amin
a:1:{s:5:"en_US";s:30:"Universitas Bakti Tunas Husada";}
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Literature Review Of Drug-Receptor Interactions Based On Molecular Docking From The Perspective Of Lock And Key Theory Saeful Amin Saeful Amin; Nazmie Nurtsalis; Dina Sumida Rosydiana; Andra Nadya Hidayat
International Journal of Health Engineering and Technology Vol. 5 No. 1 (2026): IJHET MAY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i1.842

Abstract

Drug-receptor interactions are the primary basis for determining the effectiveness of a therapy. Understanding the mechanisms of these interactions continues to evolve with advances in computational technology, one of which is through the molecular docking approach. This method enables in silico analysis of ligand-receptor interactions, including predictions of binding affinity, complex stability, and the types of molecular interactions that occur. Furthermore, the lock and key theory is a fundamental concept in explaining the structural compatibility between drugs and receptors, which influences bond strength and specificity. The method used in this review is a literature review from various scientific databases such as PubMed, Google Scholar, and ScienceDirect, with journals published in 2020 or later as inclusion criteria. The results show that oseltamivir has high affinity for neuraminidase through specific interactions such as hydrogen bonding and electrostatic binding. However, mutations in the receptor can lead to drug resistance. Therefore, understanding the mechanisms of molecular interactions is crucial for the development of more effective antiviral drugs.
Medicinal Chemistry Review Of Bioactive Compounds In Moringa Leaves (Moringa Oleifera) As Natural Antioxidants Saeful Amin Saeful Amin; Delya Annisa Putri; Syalwa Nazmi Diki; Melvi Dwi Ariani
International Journal of Health Engineering and Technology Vol. 5 No. 1 (2026): IJHET MAY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i1.864

Abstract

Moringa oleifera leaves are widely used in the health sector due to their rich content of bioactive compounds with potential as natural antioxidants. Secondary metabolites such as flavonoids, polyphenols, alkaloids, tannins, saponins, steroids, and triterpenoids play an important role in scavenging free radicals and protecting cells from oxidative damage. This article aims to review the potential of bioactive compounds in Moringa oleifera leaves as antioxidants from a medicinal chemistry perspective. The study was conducted using a literature review method by analyzing national and international scientific articles published between 2020 and 2026 from Google Scholar, PubMed, and ScienceDirect databases. The findings indicate that the antioxidant activity of Moringa oleifera leaves is mainly influenced by flavonoids and phenolic compounds. In addition, extraction methods, drying processes, fermentation, and formulation techniques also affect the effectiveness of antioxidant activity. Several studies further report that Moringa oleifera leaves have strong potential to be developed into pharmaceutical preparations and health products due to the stability of their active compounds. Overall, Moringa oleifera leaves represent a promising natural antioxidant source for further development in the field of pharmaceutical science based on natural products.
Co-Authors Andra Nadya Hidayat Delya Annisa Putri Dina Sumida Rosydiana Melvi Dwi Ariani Nazmie Nurtsalis Syalwa Nazmi Diki