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All Journal Didaktik : Jurnal Ilmiah PGSD STKIP Subang
Racmawati
Universitas Negeri Makassar
Education

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Mekanisme Molekuler Probiotik dalam Modulasi Fungsi Barrier Usus dan Respons Imun: A Systematic Literature Review Nurfadillah Salam; Aufa Hudzhaifah; Racmawati
Didaktik : Jurnal Ilmiah PGSD STKIP Subang Vol. 12 No. 02 (2026): Volume 12 No. 2, Juni 2026 Public
Publisher : STKIP Subang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36989/didaktik.v12i02.17169

Abstract

This study reviews the molecular mechanisms of probiotics in maintaining intestinal barrier function and regulating inflammation through a Systematic Literature Review of 21 selected articles from the Scopus database (2023–2026). The findings show that probiotics strengthen intestinal barrier integrity by modulating the TLR–NF-κB–MAPK pathway, increasing tight junction protein expression, regulating mitochondrial apoptosis, and influencing SCFA metabolism, bile acids, and the Akt/mTOR pathway. Evidence from in vitro, in vivo, and multi-omics studies supports the protective role of probiotics against intestinal inflammation. Overall, probiotics demonstrate strong potential as microbiome-based therapeutic agents, although further clinical validation is still required.
Co-Authors Aufa Hudzhaifah Nurfadillah Salam