The aim of this research is to identify the model of Integration of Islam and Science in Learning at Private Islamic Religious Colleges in Pekanbaru City and to explore the supporting and inhibiting factors influencing its implementation. This study employed a qualitative research approach. Data were collected through observation and interviews and analyzed descriptively. The findings reveal that the Integration of Islam and Science in Learning at Private Islamic Religious Colleges in Pekanbaru City is implemented through the Cross-Philosophical Integration Model, which is grounded in the values of Pancasila. The integration is institutional in nature, emphasizing mutual support between Islamic values and scientific knowledge in achieving learning objectives. This integration is reflected in various learning components, including objectives, curriculum and learning materials, methods, media, and evaluation. The supporting factors include strong institutional commitment, the enthusiasm and collaboration of lecturers and leaders, and improved relationships between lecturers and students. Meanwhile, the inhibiting factors consist of limited awareness among some lecturers and educational staff, insufficient understanding of the integration concept, inadequate campus environment and infrastructure, and a curriculum that has not fully accommodated the integration of Islam and science. The implications of this research indicate that the Cross-Philosophical Integration Model can serve as a conceptual and practical framework for strengthening the integration of Islam and science in learning at Islamic higher education institutions. Furthermore, the findings contribute to the development of policies, curriculum design, and learning practices that promote a more holistic, integrative, and value-based educational system.