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All Journal JPP Jurnal Kesehatan Poltekkes Palembang Science Midwifery
Rieke Dwi Ramadhany
Universitas Sriwijaya, Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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KORELASI NILAI LAJU ENDAP DARAH (LED) DENGAN HIGH SENSITIVITY C-REACTIVE PROTEIN (hs-CRP) PADA PEROKOK AKTIF DI WARUNG KOPI WILAYAH SURABAYA TIMUR Rieke Dwi Ramadhany; Evy Diah Woelansari; Christ Kartika Rahayuningsih; Nadi Aprilyadi
JPP JURNAL KESEHATAN POLTEKKES PALEMBANG Vol 17 No 2 (2022): JPP (Jurnal Kesehatan Poltekkes Palembang)
Publisher : POLITEKNIK KESEHATAN KEMENKES PALEMBANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jpp.v17i2.1297

Abstract

Background Smoking has become one of the leading causes of death worldwide. The negative impact of smoking usually occurs after a few years when a person starts actively smoking can harm the body's organs and become a major risk factor for diseases with inflammatory components. Systemic inflammatory reactions are characterized by an increase in inflammatory cytokines, blood cell counts and blood viscosity. Examination CRP and ESR are the two most frequently measured laboratory tests in assessing the response of a systemic inflammatory process. This study aims to determine and analyze the correlation between ESR values ​​and hs-CRP in active smokers at coffee shops, East Surabaya. Methods: The type of research used is correlation research with cross sectional. The sample used is 30 active smokers who meet the inclusion criteria. This research was carried out on February 21 – April 11, 2022. The examination of ESR values ​​and hs-CRP levels was carried out at Balai Besar Laboratorium Kesehatan (BBLK) Surabaya. Results: It was found that 30 respondents had been actively smoking >5 years with a percentage of 100%. as many as 8 respondents consumed 1-10 cigarettes/day with a percentage of 27%, 19 respondents consumed 10-20 cigarettes per/with a percentage of 63%, and 3 respondents consumed >20 cigarettes/day with a percentage of 10%. The average value of ESR is 8.37 mm/Hr and The The average value of the of hs-CRP 1.11 mg/L. Conclusion: Based on statistical tests, There is no correlation between the value of ESR and hs-CRP in active smokers in a coffee shop in the East Surabaya area (p value = 0.099) with a sufficient relationship and a positive direction of relationship (r = 0.307).
Molecular and transcriptional regulation of the interleukin-10 gene: Implications of the -1082 G/A promoter polymorphism on the immune response in pulmonary tuberculosis Rieke Dwi Ramadhany; Desi Oktariana; Kemas Yakub Rahadiyanto
Science Midwifery Vol 14 No 3 (2026): August: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i3.2399

Abstract

Background: Host immune responses critically determine tuberculosis outcomes. Although the interleukin-10 (IL-10) -1082 G/A promoter polymorphism alters IL-10 expression and pulmonary tuberculosis susceptibility, global studies report conflicting findings that lack a comprehensive molecular synthesis. Objective: This review critically evaluates IL-10 molecular regulation and the immunological and clinical implications of the -1082 G/A polymorphism in pulmonary tuberculosis. Methods: A narrative literature review utilized PubMed, ScienceDirect, and Google Scholar (2008–2026). Employing a structured literature selection flowchart and the Joanna Briggs Institute (JBI) Critical Appraisal tools for quality assessment, 55 high-quality articles were ultimately selected and synthesized narratively. Results: The G allele exhibits greater affinity for the Sp1 transcription factor, increasing IL-10 expression. This hyper-secretion suppresses macrophage activation and Th1-mediated immunity via the JAK/STAT pathway. Crucially, susceptibility differences among populations are heavily influenced by linkage disequilibrium, ethnic genetic diversity, epigenetic regulation, and gene–environment interactions. Conclusion: This review provides an integrated perspective linking the IL-10 promoter polymorphism with immune regulation, highlighting its potential as a predictive biomarker for precision medicine and risk stratification in vulnerable demographics. Large-scale, multi-ethnic longitudinal studies integrating genetic and epigenetic analyses are recommended.
Co-Authors Aprilyadi, Nadi Desi Oktariana Evy Diah Woelansari Kartika Rahayuningsih, Christ Kemas Yakub Rahadiyanto