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All Journal Jurnal Kedokteran Bali Medical and Wellness Journal
Dananjaya, I Made Dwi
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Hubungan Masa Kerja dengan Kapasitas Fungsi Paru pada Pekerja Pembakaran Amalgam di Kecamatan Sekotong Dananjaya, I Made Dwi; Widiastuti, Ida Ayu Eka; Ekawanti, Ardiana
Jurnal Kedokteran Vol 6 No 3.1 (2017)
Publisher : Faculty of Medicine Universitas Mataram

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Abstract

Latar belakang: Pertambangan Emas Skala Kecil (PESK) merupakan sumber terbesar emisi merkuri dari emisi merkuri global. Paparan merkuri dapat menyebabkan berbagai masalah kesehatan salah satunya terhadap gangguan fungsi paru. Data dan penelitian mengenai hal ini di Indonesia masih sangat kurang sehingga perlu dilakukan penelitian untuk mengetahui hubungan masa kerja dengan kapasitas fungsi paru pada pekerja pembakaran amalgam di Kecamatan Sekotong. Metode: Penelitian ini merupakan penelitian deskriptif analitik dengan rancangan potong lintang. Populasi penelitian adalah pekerja pembakaran amalgam di Kecamatan Sekotong. Jumlah sampel dalam penelitian ini sebesar 34 subjek penelitian. Pengambilan data dilakukan dengan wawancara untuk pengisian data dan pemeriksaan fungsi paru dengan spirometer. Analisis data menggunakan uji korelasi Spearman. Hasil: Dari 34 subjek penelitian, terdapat 10 orang (29,41%) dengan gangguan fungsi paru restriktif dan 24 orang (71,59%) dengan gangguan campuran. Berdasarkan uji korelasi Spearman diperoleh hasil bahwa masa kerja berpengaruh signifikan terhadap nilai FEV1 (p = 0,027) dengan korelasi yang lemah (r = -0,380 ) dan FVC (p = 0,019) dengan korelasi yang sedang (r = -0,401). Kesimpulan: Masa kerja berhubungan dengan kapasitas fungsi paru pada pekerja pembakaran amalgam di Kecamatan Sekotong.
Harnessing Mycoprotein: Unravelling Its Impact on Skeletal Muscle Health Through Systematic Review and Meta-Analysis Dewi, Made Yudha Asrithari; Pangkahila, Evangelista Maria; Dananjaya, I Made Dwi
Bali Medical and Wellness Journal Vol. 1 No. 3 (2024): Bali Medical and Wellness Journal
Publisher : PT BMW Journal Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71341/bmwj.v1i3.23

Abstract

Background: Mycoprotein, a fungal-derived protein from Fusarium venenatum, has gained attention for its potential benefits in muscle health, particularly as an alternative to traditional animal-based proteins. Objectives: This systematic review and meta-analysis aimed to evaluate the effects of mycoprotein intake on skeletal muscle protein synthesis, plasma branched-chain amino acids (BCAAs), and post-prandial insulin response in healthy adults. Methods: The study followed the PRISMA guidelines and was registered in PROSPERO (CRD42024602558). A comprehensive search of the PubMed, Scopus, EuropePMC and Cochrane Library databases was conducted to identify randomized controlled trials comparing mycoprotein interventions with non-mycoprotein control groups. Trials were included if they reported outcomes related to muscle protein synthesis, plasma amino acid levels, or post-prandial insulin response. Risk of bias was assessed using the Cochrane risk-of-bias tool. Meta-analyses were performed using an inverse-variance–weighted, random-effects model. Results: Four randomized controlled trials involving 82 participants were included. Mycoprotein intake significantly increased muscle protein synthesis rates, with a fractional synthetic rate (FSR) increase of +0.01% per hour (95% CI: 0.01% to 0.02%, P < 0.001) compared to control groups. There was no significant difference in plasma BCAA levels between mycoprotein and control groups (mean difference: 2.83 µmol/L, 95% CI: -84.93 to 90.58, P > 0.05). However, post-prandial insulin response was significantly higher in the mycoprotein group at 30 minutes post-ingestion (mean difference: 8.15 mU/L, 95% CI: 5.70 to 10.59, P < 0.001). Conclusions: Mycoprotein intake shows potential benefits for increasing muscle protein synthesis and enhancing post-prandial insulin response. However, the limited sample sizes and short durations of the included trials suggest the need for larger, long-term studies to confirm these findings.
Co-Authors Ardiana Ekawanti Dewi, Made Yudha Asrithari Ida Ayu Eka Widiastuti Pangkahila, Evangelista Maria