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All Journal Journal of Multidisciplinary Applied Natural Science
Mulyadi Tanjung
Department of Chemistry,Universitas Airlangga, Surabaya-60115 (Indonesia)
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Physics

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Prenylated Xanthones from Calophyllum biflorum Leaves: Isolation, Structural Characterization, and Evaluation of Antioxidant and Cytotoxic Activities Fitri Nurvita Sari; Harum Margasari; Leny Nur Fitriani; Novian Ilham Ramadhan; Muhammad Ulul ‘Azmi; Mulyadi Tanjung; Tjitjik Srie Tjahjandarie; Ratih Dewi Saputri
Journal of Multidisciplinary Applied Natural Science Vol. 6 No. 3 (2026): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.462

Abstract

The Calophyllum genus, part of the Calophyllaceae family, produces xanthones as dominant secondary metabolites. Calophyllum biflorum M.R. Hend. & Wyatt-Sm. is an endemic plant of Kalimantan; however, the potential of its xanthone content and biological activity has never been explored. In this study, three known prenylated xanthones: gartanin (1), ananixanthone (2), and α-mangostin (3), were isolated from C. biflorum leaves. Their chemical structures were determined by HRMS and 1D/2D NMR. The antioxidant activities of xanthones 1–3 (via DPPH radical) and their cytotoxicity toward 4T1 breast cancer cells were assessed. Xanthones 1–2 showed strong DPPH activity (IC50: 4.40 and 34.34 µM, respectively). Gartanin (1) also exhibited moderate activity against 4T1 cells (IC50 =16.70 µM). These results indicate the prenylated xanthones from C. biflorum as antioxidant agents.
Co-Authors Fitri Nurvita Sari Harum Margasari Leny Nur Fitriani Muhammad Ulul ‘Azmi Novian Ilham Ramadhan Ratih Dewi Saputri Tjitjik Srie Tjahjandarie