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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Hafis Novyan
Faculty of Medicine Universitas Syah Kuala Dr. Zainoel Abidin General Hospital Banda Aceh
Health Professions Medicine & Pharmacology Public Health

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Maternal Vitamin D and Its Role in Amniotic Membrane Thickness in Premature Rupture of Membranes Hafis Novyan; Rajuddin Rajuddin; Niken Asri Utami
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 2 April 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i2.2013

Abstract

AbstractObjective: To examine the correlation between maternal serum vitamin D levels and amniotic membrane thickness in cases of premature rupture of membranes (PROM).Methods: This analytical cross-sectional study was conducted from July to November 2022 at Dr. Zainoel Abidin General Hospital, the Universitas Syiah Kuala Research Laboratory, and Prodia Banda Aceh Laboratory. A total of 30 women with term PROM who met the inclusion and exclusion criteria were enrolled. Serum vitamin D levels were measured using Electrochemiluminescence Immunoassay (ECLIA), while amniotic membrane thickness was assessed histologically using hematoxylin Eosin (HE) staining. Spearman’s correlation test was performed with a 95% confidence level.Results: Thirty mothers with PROM were included, with a mean age of 31.37 ± 6.8 years. Vaginal delivery was the predominant mode of delivery (53.3%). The mean serum vitamin D level was 20.25 ng/mL (range: 8.5–42.5 ng/mL), and the mean amniotic membrane thickness was 82.51 µm (range: 28.69–227.8 µm). No significant correlation was observed between serum vitamin D levels and amniotic membrane thickness (r = −0.029; p = 0.878).Conclusion: There was no significant correlation between maternal serum vitamin D levels and amniotic membrane thickness in cases of PROM.Keywords: amnion, pregnancy, premature rupture of membranes, thickness of the membranes, vitamin D.
Co-Authors Niken Asri Utami Rajuddin Rajuddin