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All Journal Journal of Pharmaceutical and Sciences.
Larisa Sabrina Rahadiyanti
Department of Dermatology, Venereology and Aesthetic, Faculty of Medicine, Universitas Sebelas Maret / Dr. Moewardi General Hospital, Surakarta, Central Java, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Gambaran Imunohistokimia pada Pasien Infeksi Herpes Simplex Virus 1 dengan Karsinoma Tiroid: Sebuah Serial Kasus Putri Jati Utami; Prasetyadi Mawardi; Triasari Oltavriana; Utiya Nur Laili; Larisa Sabrina Rahadiyanti
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1603

Abstract

Thyroid carcinoma is one of the most common endocrine cancers with a multi-factorial etiology. The role of HSV-1 in the pathogenesis of thyroid cancer remains an area of ongoing investigation. HSV-1 may be present in thyroid tissue raising questions about its potential role in thyroid carcinogenesis. The first case involves a 65-year-old male diagnosed with thyroid carcinoma, presenting with a history of oral discomfort and pain two weeks before evaluation. The second case is a 73-year-old male, also diagnosed with thyroid carcinoma with no history of herpes simplex virus (HSV). Both patients underwent thyroidectomy, and histopathological examination confirmed the presence of papillary carcinoma in thyroid tissue. Immunohistochemical analysis further identified HSV-1 in both cases. A study has reported a higher frequency of HSV DNA detection in thyroid carcinoma, with a significant correlation between oncogenic mutations and HSV presence. The upregulation of nectin-1 expression in thyroid carcinoma facilitates HSV occurrence, thereby increasing the susceptibility of cancer cells to viral infection. Moreover, thyroid hormone levels may play a role in HSV reactivation, highlighting the intricate interplay between thyroid function, viral activity, and cancer progression. Histopathological examination, including immunohistochemical (IHC) staining, identified HSV 1 in two patients diagnosed with thyroid carcinoma. These findings underscore the need for further research involving a larger cohort to elucidate the potential role of HSV in thyroid carcinogenesis.
Nilai Viral Load dan Cluster of Differentiation 4 (CD-4) pada Pasien Human Immunodeficiency Virus (HIV) sebagai Penanda Infeksi Menular Seksual Utiya Nur Laili; Endra Yustin Ellistasari; Putri Jati Utami; Larisa Sabrina Rahadiyanti
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1615

Abstract

Human immunodeficiency virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) infection is a major problem in developing countries. Co-infection with sexually transmitted infections (STIs) in HIV patients is a comorbid factor increasing the risk of HIV and STI transmission. CD4 T lymphocyte cell levels and viral load are used for immunologic and virologic success of HIV/AIDS patients. Studies linking CD4 T lymphocyte counts, viral load and STI incidence in HIV/AIDS patients are few and variable. This research aim to evaluate the CD4 and viral load values in HIV/AIDS patients at Dr. Moewardi Hospital with the incidence of STIs. Retrospective study using secondary data from the medical records of the Voluntary Counseling and Testing (VCT) clinic at Dr. Moewardi Hospital for the period January 2022 - December 2024. Sexually transmitted infections diagnosis was based on syndromic approach. Data CD4 of STI patients with HIV/AIDS were recorded for statistical processing using SPSS version 26. Numerical data were tested for normality using the Kolmogorov-Smirnov test (p>0.05). Normally distributed data were subjected to unpaired t-test, non-normally distributed data were subjected to Mann-Whitney test, categorical data were subjected to chi-square test with a significance of p<0.05. CD4 data were then assessed for sensitivity, specificity and cut-off values. Cases of HIV patients with STIs were predominantly male with an average age of 33.94 years. Statistical analysis showed gender (p=<0.001), occupation (p=0.018) age (p<0.001), and ARV duration (p=0.037), while education level (p=0.448) and viral load (p=0.417). CD4 count (p=0.027) had p<0.05, AUC for CD4 was 0.648 with p=0.030, cutoff 459.5, sensitivity 66.7% and specificity 62.5%, OR=3.33 and p=0.013. There is an association between CD4 levels and the incidence of STIs in HIV patients with a sensitivity of 66.7%, specificity of 62.5% and a cutoff value of 459.5, HIV patients with CD4 <459.5 have a risk of STIs by 3.33 times compared to HIV patients who have CD 4 ≥459.5 (OR = 3.33; p = 0.013).
Co-Authors Endra Yustin Ellistasari Prasetyadi Mawardi Putri Jati Utami Putri Jati Utami Triasari Oltavriana Utiya Nur Laili