Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Malacca Pharmaceutics
Noviyanti Noviyanti
Graduate School of Mathematics and Applied Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia; Department of Midwifery, Polytechnic of Health Ministry of Health, Aceh Besar 23352, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Evaluating the Effects of Young Areca catechu Seed Extract on FSH and Testosterone Levels in Male Rats: Insights into Natural Anti-Fertility Agents Noviyanti Noviyanti; Sugito Sugito; Muslim Akmal; Nurdin Saidi
Malacca Pharmaceutics Vol. 4 No. 1 (2026): March 2026
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v4i1.338

Abstract

Male participation in contraception remains limited worldwide because few safe and acceptable male contraceptive options exist. Natural products are being explored as potential regulators of male reproductive hormones. Areca catechu (areca nut), traditionally used in Southeast Asia, contains phytochemicals that may influence reproductive function. This study evaluated the effects of the ethanolic extract of young A. catechu seeds on serum follicle-stimulating hormone (FSH) and testosterone levels in male Wistar rats. Twenty-five rats were randomly assigned to five groups (0, 20, 40, 60, and 80 mg/kgbody weight) and treated daily for 48 days. Serum FSH and testosterone were measured by ELISA and analyzed by one-way ANOVA with Duncan’s post-hoc test. Mean FSH and testosterone values varied across doses, with the 40 mg/kg group showing the highest means (10.001 ± 10.413 ng/mL and 2.196 ± 1.254 ng/mL, respectively), but no statistically significant differences were detected for either hormone (FSH p = 0.043; testosterone p = 0.425). The results provide preliminary, hypothesis-generating evidence that the extract may influence the hypothalamic–pituitary–gonadal axis; however, any role in male fertility regulation remains unproven. Larger studies including sperm-quality assessment, mechanistic analyses, and toxicological evaluation are required before considering potential applications in male reproductive health.
Co-Authors Muslim Akmal Nurdin Saidi Sugito Sugito