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All Journal Malahayati International Journal of Nursing and Health Science
Febriani Febriani
Fakultas Kedokteran, Universitas Riau
Health Professions Nursing Public Health

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Management of pregnancy-associated breast cancer: A case series and review of multidisciplinary treatment approaches Fania Pancar Fadilla; Febriani Febriani
Malahayati International Journal of Nursing and Health Science Vol. 8 No. 7 (2025): Volume 8 Number 7
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v8i7.976

Abstract

Background: Pregnancy-associated breast cancer (PABC) refers to breast cancer identified either during gestation or within the first year following childbirth. Managing PABC presents distinct clinical complexities, as it necessitates a careful balance between effective maternal therapy and ensuring fetal safety. Purpose: This case series seeks to detail the clinical characteristics, diagnostic procedures, and treatment approaches utilized in managing PABC. Method: We report multiple cases involving pregnant women diagnosed with breast cancer at different stages of gestation. Information was gathered regarding clinical presentation, gestational age at diagnosis, types and timing of treatment interventions (such as surgery and chemotherapy), as well as maternal and fetal outcomes. Results: The cases underscore the critical role of early detection and a multidisciplinary team approach. Treatment strategies were tailored according to gestational age and cancer stage. Chemotherapy was generally administered without significant complications during the second and third trimesters, and surgical procedures were planned to prioritize both maternal and fetal health. Conclusion: Effective management of PABC demands close coordination between oncology and obstetrics teams. With appropriate planning and individualized care, it is possible to treat breast cancer during pregnancy without substantially endangering fetal health.
Early gestational diagnosis of alobar holoprosencephaly with omphalocele: A case report Ninda Frymonalitza; Febriani Febriani
Malahayati International Journal of Nursing and Health Science Vol. 8 No. 9 (2025): Volume 8 Number 9
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v8i9.1241

Abstract

Background: Holoprosencephaly (HPE) is the most frequent congenital brain malformation, with alobar HPE representing the most severe form. It is often accompanied by other structural anomalies such as omphalocele, significantly complicating fetal prognosis and perinatal management. Purpose: To present the early gestational diagnosis of alobar holoprosencephaly with omphalocele. Method: A descriptive case report of a 40-year-old gravida 2 para 1 woman whose fetus was diagnosed via ultrasound at 17–18 weeks' gestation with alobar HPE and omphalocele. The case was managed through routine antenatal care and serial ultrasound monitoring. Results: Serial imaging revealed progressive ventriculomegaly and worsening abdominal wall defect. Despite the fatal nature of the anomalies, legal constraints in Indonesia prevented pregnancy termination. The fetus survived until intrauterine demise at 37–38 weeks, after which labor was induced and a stillborn delivered vaginally. Conclusion: This case underscores the importance of early gestational diagnosis and highlights the ethical and legal challenges in managing lethal fetal anomalies in restrictive settings. Comprehensive parental counseling and genetic evaluation are crucial components in delivering informed care.
Complex neonatal neurological anomalies: A case report of hydrocephalus, hydranencephaly, and holoprosencephaly Muhammad Ilham; Febriani Febriani
Malahayati International Journal of Nursing and Health Science Vol. 8 No. 11 (2026): Volume 8 Number 11
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v8i11.1618

Abstract

Background: Hydrocephalus, hydranencephaly, and holoprosencephaly are severe neurodevelopmental disorders that significantly impact brain structure and function. Early identification and appropriate management are essential to reduce morbidity and mortality, yet clinical differentiation among these conditions remains challenging. Purpose: To explore the pathophysiological mechanisms, clinical outcomes, and current management approaches for hydrocephalus, hydranencephaly, and holoprosencephaly, with a focus on improving diagnostic accuracy and therapeutic strategies. Method: This retrospective study was conducted at Arifin Achmad Hospital, Pekanbaru, over a five-year period (July 2018–July 2023), reviewing medical records of neonates diagnosed with major neurological anomalies such as hydrocephalus, hydranencephaly, and holoprosencephaly, confirmed by imaging or clinical evaluation. Results: The findings reveal that hydrocephalus is primarily characterized by abnormal cerebrospinal fluid accumulation, hydranencephaly involves near-complete cerebral hemisphere loss replaced by cerebrospinal fluid, and holoprosencephaly results from impaired prosencephalon division during early embryogenesis. Advances in genetic testing and neuroimaging have enhanced differential diagnosis, while early neurosurgical intervention and multidisciplinary care significantly improve survival and quality of life. Conclusion: Understanding the distinct pathophysiology and outcomes of these disorders is crucial for effective patient care. Future research in genetic and neurodevelopmental pathways offers promising opportunities for targeted therapies and improved long-term management.
Co-Authors Fania Pancar Fadilla Muhammad Ilham Ninda Frymonalitza