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All Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan
Endah Hamidah Abbas
Department of Anatomical Pathology, Faculty of Medicine, Universitas Jenderal Achmad Yani, Cimahi, Indonesia
Health Professions Medicine & Pharmacology

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Histopathological Evaluation of the Hepatoprotective Effect of Pineapple Peel Extract (Ananas comosus) in Paracetamol-Induced Wistar Rats Teja Koswara; Tamara Putri Rahayu; Elly Noer Rochmah; Endah Hamidah Abbas
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 20 No 1 (2026): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan (In Press)
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v20i1.14051

Abstract

Paracetamol is a leading cause of drug-induced liver injury (DILI) through the formation of the toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI), which induces oxidative stress and hepatocellular damage. Natural antioxidants have potential as hepatoprotective agents. Pineapple peel (Ananas comosus), an agricultural by-product, contains bioactive compounds such as bromelain, flavonoids, and vitamin C with antioxidant and anti-inflammatory properties. This study aimed to evaluate the hepatoprotective effect of pineapple peel extract against paracetamol-induced liver injury in Wistar rats. This experimental study used a post-test only control group design with 30 male Wistar rats divided into six groups (n = 5): negative control, positive control (paracetamol 2.5 g/kg body weight), and four treatment groups receiving pineapple peel extract at doses of 250, 500, 750, and 1,000 mg/kg body weight prior to paracetamol induction. Liver tissues were examined histopathologically using Hematoxylin–Eosin staining and assessed with the Suzuki scoring system. Data were analyzed using Kruskal–Wallis and Mann–Whitney tests. There was a significant difference in liver damage scores among groups (p = 0.003). The 750 mg/kg dose showed the most effective hepatoprotective effect (p = 0.043). In conclusion, pineapple peel extract exhibits hepatoprotective potential against paracetamol-induced liver injury. Keywords: Ananas comosus, hepatoprotective, paracetamol, liver histopathology.
Co-Authors Elly Noer Rochmah Tamara Putri Rahayu Teja Koswara