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All Journal International Journal of Health and Pharmaceutical (IJHP)
Reinaldo Putra Hardian
Acinic Cell Carcinoma; Parotid Gland; Transarterial Chemoembolization; Radical Neck Dissection an Case Report.
Nursing Public Health

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Successful Multimodality Management of Advanced Acinic Cell Carcinoma of The Parotid Gland: A Case Report Christian O. Manginstar; Reinaldo Putra Hardian
International Journal of Health and Pharmaceutical (IJHP) Vol. 6 No. 3 (2026): August 2026
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v6i3.713

Abstract

Background Acinic cell carcinoma (ACC) is a rare malignant salivary gland tumor that predominantly arises in the parotid gland. Although generally considered a low-grade malignancy, locally advanced or recurrent disease presents significant therapeutic challenges because of its infiltrative behavior and the absence of standardized treatment strategies. Case Presentation: A 56-year-old man presented with a recurrent painful left submandibular mass three years after previous surgical excision. Magnetic resonance imaging demonstrated a large left parotid tumor with mandibular erosion. The patient underwent neoadjuvant transarterial chemoembolization (TACE), followed by wide tumor excision, radical neck dissection, and immediate deltopectoral flap reconstruction. Histopathological examination confirmed acinic cell carcinoma of the parotid gland with a pathological stage of ypT4aN0M0 (Stage IVA). The postoperative course was uneventful, with satisfactory wound healing and viable flap reconstruction. A second-stage flap division was successfully performed without complications. Conclusion: This case demonstrates that multimodality management incorporating neoadjuvant TACE, radical surgical resection, and reconstructive surgery can provide favorable short-term oncologic and functional outcomes in selected patients with advanced recurrent acinic cell carcinoma of the parotid gland. Multidisciplinary collaboration remains essential for individualized treatment planning in this rare malignancy.
Co-Authors Christian O. Manginstar