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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA)
Ni’matul Murtafi’ah
Rajawali Health Institute
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology Physics

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Implementation of Six Sigma as A Quality Control Evaluation of Routine Blood Testing on The Sysmex Xn-1000 Hematology Analyzer Aziz Ansori Wahid; Ally Kafesa; Ni’matul Murtafi’ah; Cep Wahyu
Jurnal Penelitian Pendidikan IPA Vol 12 No 7 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i7.15802

Abstract

This study aimed to evaluate the analytical performance of routine hematology parameters on the Sysmex XN-1000 Hematology Analyzer using the Six Sigma approach. A quantitative descriptive study with an evaluative design was conducted using secondary internal quality control data collected from the Bandung City Regional Health Laboratory during February–March 2025. The analyzed parameters included hemoglobin (HGB), hematocrit (HCT), leukocytes (WBC), platelets (PLT), and erythrocytes (RBC) at three levels of control materials. Precision was assessed using the coefficient of variation (CV), while accuracy and total allowable error (TEa) were used to calculate sigma metrics. Parameters with sigma values below four were further evaluated using the Quality Goal Index (QGI). The results demonstrated that all parameters had acceptable precision, with CV values below 0.33 TEa, and total error values remained within the allowable limits. Hemoglobin and erythrocyte parameters exhibited excellent analytical performance (5–6 sigma), while leukocyte parameters achieved world-class performance (>6 sigma). Hematocrit and platelet parameters showed good performance (4–5 sigma), whereas several parameters with sigma values below four indicated problems related to imprecision, inaccuracy, or both. The findings indicate that the analytical performance of the Sysmex XN-1000 is generally satisfactory and support the implementation of Sigma Matrix-based quality control strategies to improve laboratory efficiency and reliability.
The Effect of Giving Insulin Leaf Extract (Smallanthus sonchifolius) on the Reduction of the Number of Leukocytes in Wistar Rats Infected with Staphylococcus aureus Ni’matul Murtafi’ah; Fitri Rahmi Fadhilah; Wasiyah Khusna F; Liah Kodriah
Jurnal Penelitian Pendidikan IPA Vol 12 No 7 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i7.15807

Abstract

This study aimed to evaluate the antibacterial activity and immunomodulatory effects of insulin leaf (Smallanthus sonchifolius) extract against Staphylococcus aureus infection in Wistar rats. The research employed an experimental design using Wistar rats divided into five groups: negative control, positive control, and treatment groups receiving insulin leaf extract at doses of 100 mg, 200 mg, and 400 mg. Leukocyte counts were measured from day 1 to day 13 following bacterial induction and treatment administration. Antibacterial activity was assessed using the well diffusion method at extract concentrations of 25%, 50%, and 75%. Statistical analysis was performed using One-Way ANOVA. The results demonstrated that insulin leaf extract significantly reduced leukocyte counts in infected rats, indicating anti-inflammatory and immunomodulatory effects. The 400 mg dose exhibited the most stable reduction in leukocyte levels throughout the observation period. Antibacterial testing showed inhibition zone diameters of 20.42 mm, 22.62 mm, and 24.90 mm at concentrations of 25%, 50%, and 75%, respectively, indicating strong to very strong antibacterial activity against Staphylococcus aureus. One-Way ANOVA revealed significant differences among treatment groups (p = 0.002) and among antibacterial concentrations (p < 0.001). These findings suggest that Smallanthus sonchifolius leaf extract possesses potent antibacterial, anti-inflammatory, and immunomodulatory properties and has potential as a natural therapeutic agent for bacterial infections caused by Staphylococcus aureus.
Co-Authors Ally Kafesa Aziz Ansori Wahid Cep Wahyu Fitri Rahmi Fadhilah Liah Kodriah Wasiyah Khusna F