Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal As-syifaa Jurnal Farmasi
Bayu Putra
Faculty of Pharmacy, Universitas Muslim Indonesia, Makassar, South Sulawesi, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus Lam.) SEBAGAI ANTIULCER BERDASARKAN PARAMETER INDEKS ULKUS PADA TIKUS JANTAN (Rattus norvegicus) YANG DIINDUKSI ASPIRIN Ira Asmaliani; Sukmawati Sukmawati; Bayu Putra; Nurfadilah Nurfadilah; Dian Aminarti; Andi Wahdania Jemma
As-Syifaa Jurnal Farmasi Vol 18, No 1 (2026): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v18i1.1519

Abstract

Peptic ulcer disease is a disorder of the upper gastrointestinal tract caused by an imbalance between aggressive and defensive factors of the gastric mucosa. This condition can be treated using Proton Pump Inhibitors (PPIs) and Histamine H₂-Receptor Antagonists (H2RAs). This study aimed to determine the anti-ulcer effect of ethanol extract of jackfruit leaves (Artocarpus heterophyllus Lam.) based on ulcer index parameters in aspirin-induced male rats (Rattus norvegicus). The study employed a Posttest-Only Control Group Design involving 18 male rats divided into six groups: positive control (omeprazole 20 mg/kg body weight), negative control (1% Na-CMC), ethanol extract of jackfruit leaves (EEJL) treatment groups at doses of 100, 200, and 300 mg/kg body weight, and a normal control group (distilled water). The obtained data were analyzed using the Kruskal–Wallis test followed by the Mann-Whitney test. The results showed that administration of ethanol extract of jackfruit leaves at a dose of 300 mg/kg body weight produced the most effective anti-ulcer activity, as indicated by an ulcer index of 2.00 and a therapeutic percentage of 84.41%.
Co-Authors Andi Wahdania Jemma Dian Aminarti Ira Asmaliani Nurfadilah Nurfadilah Sukmawati Sukmawati