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All Journal International Archives of Medical Sciences and Public Health International Archives of Medical Sciences and Public Health
Yona Mimanda
Department of Clinical Pathology, Faculty of Medicine, Syarif Hidayatullah State Islamic University, Jakarta, Indonesia
Religion Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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LONGITUDINAL DECLINE OF ANTI-S-RBD IGG ANTIBODY LEVELS AMONG LECTURERS AND EDUCATIONAL STAFF FIVE MONTHS AFTER CORONAVAC VACCINATION IN INDONESIA Nurmila Sari; Yona Mimanda; Muniroh; Dinnisa Haura Zhafira Hidayat; Tri Nurjannah
International Archives of Medical Sciences and Public Health Vol. 7 No. 1 (2026): International Archives of Medical Sciences and Public Health
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v7i1.1452

Abstract

Humoral immunity induced by the CoronaVac vaccine may decline overtime. This study assessed changes in anti-spike receptor-binding domain (S-RBD) immunoglobulin G (IgG) antibody levels at 1 month and 5 months after completion of the two-dose CoronaVac regimen. A prospective observational cohort study was conducted among 54 participants, with 28 completing paired antibody measurements. Serum anti-S-RBD IgG concentrations were measured using a chemiluminescence microparticle immunoassay (CMIA), and differences between time points were analyzed using the Wilcoxon signed-rank test. A significant decline in antibody levels was observed, with the median concentration decreasing from 521.1 AU/mL (range: 71.2–2109.4) at 1 month to 57.8 AU/mL (range: 49.0–512.4) at 5 months, representing an approximately 89% reduction (p < 0.001). The Hodges Lehmann estimated median difference was -426.125 AU/mL (95% CI: -633.550 to -260.500). These findings indicate waning humoral immunity within five months after the second CoronaVac dose and support consideration of booster vaccination strategies.
LONGITUDINAL DECLINE OF ANTI-S-RBD IGG ANTIBODY LEVELS AMONG LECTURERS AND EDUCATIONAL STAFF FIVE MONTHS AFTER CORONAVAC VACCINATION IN INDONESIA Nurmila Sari; Yona Mimanda; Muniroh; Dinnisa Haura Zhafira Hidayat; Tri Nurjannah
International Archives of Medical Sciences and Public Health Vol. 7 No. 1 (2026): International Archives of Medical Sciences and Public Health
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v7i1.1452

Abstract

Humoral immunity induced by the CoronaVac vaccine may decline overtime. This study assessed changes in anti-spike receptor-binding domain (S-RBD) immunoglobulin G (IgG) antibody levels at 1 month and 5 months after completion of the two-dose CoronaVac regimen. A prospective observational cohort study was conducted among 54 participants, with 28 completing paired antibody measurements. Serum anti-S-RBD IgG concentrations were measured using a chemiluminescence microparticle immunoassay (CMIA), and differences between time points were analyzed using the Wilcoxon signed-rank test. A significant decline in antibody levels was observed, with the median concentration decreasing from 521.1 AU/mL (range: 71.2–2109.4) at 1 month to 57.8 AU/mL (range: 49.0–512.4) at 5 months, representing an approximately 89% reduction (p < 0.001). The Hodges Lehmann estimated median difference was -426.125 AU/mL (95% CI: -633.550 to -260.500). These findings indicate waning humoral immunity within five months after the second CoronaVac dose and support consideration of booster vaccination strategies.
Co-Authors Dinnisa Haura Zhafira Hidayat Muniroh Nurmila Sari Tri Nurjannah