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All Journal Andalas obstetrics and gynecology journal
Jesica Putri Salim
Medical Professional Education, Faculty of Medicine, Sriwijaya University, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Nursing Public Health

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Meta-analisis: letrozole vs clomiphene citrate sebagai induksi ovulasi pada PCOS Jesica Putri Salim; Raissa Nurwany; Iche Andriyani Liberty; Hanif Gusneri Syahbiran
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 2 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.2.218-233.2026

Abstract

Objective: Polycystic Ovarian Syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age, characterized by symptoms such as hyperandrogenism, irregular menstrual cycles, and polycystic ovaries. This systematic review and meta-analysis aim to evaluate the efficacy of Letrozole, an aromatase inhibitor, inducing ovulation compared to Clomiphene Citrate (CC) in women with PCOS Method: Studies published between 2020 and 2024 were included, following PRISMA guidelines and utilizing the PICOS framework. Seven randomized controlled trials (RCTs) involving 1,037 women diagnosed with PCOS based on the Rotterdam criteria met the inclusion criteria Result: The meta-analysis showed Letrozole had a slightly higher ovulation rate (68.5% vs. 60.5% for CC), though the difference was not significant (RR 1.13, 95% CI 1.00–1.28, P = 0.06, I² = 10%). However, Letrozole significantly improved pregnancy rates (26.4% vs. 18.4% for CC; RR 1.42, 95% CI 1.02–1.99, P = 0.04, I² = 0%) Conclusion: The findings support Letrozole as a viable and potentially more practical option than Clomiphene Citrate for ovulation induction in women with PCOS, particularly in improving pregnancy rates. Future research should focus on optimizing treatment regimens and exploring long-term effects to further enhance fertility outcomes for this population. Keywords: letrozole; aromatase inhibitor; clomiphene citrate; polycystic ovarian syndrome; ovulation induction.
Co-Authors Hanif Gusneri Syahbiran Iche Andriyani Liberty Raissa Nurwany